TY - JOUR
T1 - Prognostic significance of epidermal growth factor receptor in laryngeal squamous cell carcinoma
AU - Maurizi, Maurizio
AU - Almadori, Giovanni
AU - Ferrandina, Maria Gabriella
AU - Distefano, M.
AU - Romanini, M. E.
AU - Cadoni, Gabriella
AU - Benedetti-Panici, P.
AU - Paludetti, Gaetano
AU - Scambia, Giovanni
AU - Mancuso, S.
PY - 1996
Y1 - 1996
N2 - Epidermal growth factor receptor (EGFR) content was determined by a radioligand receptor assay in 140 primary laryngeal squamous cell carcinomas (median value of 8.4 fmol mg-1 protein, range 0-169.9 fmol mg-1 protein). Cox univariate regression analysis using EGFR as a continuous variable showed that EGFR levels are directly associated with the risk of death (χ2, 14.56, P-value = 0.0001) and relapse (χ2 = 7.77, P-value = 0.0053). A significant relationship between EGFR status and survival was observed at the different arbitrary cut-off values chosen (8, 16 and 20 fmol mg-1 protein). The cut-off value of 20 fmol mg-1 protein was the best prognostic discriminator. In fact, the 5 year survival was 81% for patients with EGFR- tumours compared with 25% for patients with EGFR+ tumours (P < 0.0001). The 5 year relapse-free survival was 77% for patients with EGFR- tumours compared with 24% for patients with EGFR+ tumours (P < 0.010). When clinicopathological parameters and EGFR status were examined in the multivariate analysis, T classification and EGFR status retained an independent prognostic value. In this study we demonstrated that high EGFR levels single out patients with poor prognosis in laryngeal cancer.
AB - Epidermal growth factor receptor (EGFR) content was determined by a radioligand receptor assay in 140 primary laryngeal squamous cell carcinomas (median value of 8.4 fmol mg-1 protein, range 0-169.9 fmol mg-1 protein). Cox univariate regression analysis using EGFR as a continuous variable showed that EGFR levels are directly associated with the risk of death (χ2, 14.56, P-value = 0.0001) and relapse (χ2 = 7.77, P-value = 0.0053). A significant relationship between EGFR status and survival was observed at the different arbitrary cut-off values chosen (8, 16 and 20 fmol mg-1 protein). The cut-off value of 20 fmol mg-1 protein was the best prognostic discriminator. In fact, the 5 year survival was 81% for patients with EGFR- tumours compared with 25% for patients with EGFR+ tumours (P < 0.0001). The 5 year relapse-free survival was 77% for patients with EGFR- tumours compared with 24% for patients with EGFR+ tumours (P < 0.010). When clinicopathological parameters and EGFR status were examined in the multivariate analysis, T classification and EGFR status retained an independent prognostic value. In this study we demonstrated that high EGFR levels single out patients with poor prognosis in laryngeal cancer.
KW - Epidermal growth factor receptor
KW - Larynx
KW - Prognosis
KW - Squamous cell carcinoma
KW - Epidermal growth factor receptor
KW - Larynx
KW - Prognosis
KW - Squamous cell carcinoma
UR - http://hdl.handle.net/10807/209964
U2 - 10.1038/bjc.1996.525
DO - 10.1038/bjc.1996.525
M3 - Article
SN - 0007-0920
VL - 74
SP - 1253
EP - 1257
JO - British Journal of Cancer
JF - British Journal of Cancer
ER -