Prognostic significance of epidermal growth factor receptor in laryngeal squamous cell carcinoma

Giovanni Almadori, Maria Gabriella Ferrandina, Gabriella Cadoni, Gaetano Paludetti, Giovanni Scambia, Salvatore Mancuso, Maurizi 1 M, M Distefano, M E Romanini, P Benedetti-Panici

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Epidermal growth factor receptor (EGFR) content was determined by a radioligand receptor assay in 140 primary laryngeal squamous cell carcinomas (median value of 8.4 fmol mg-1 protein, range 0-169.9 fmol mg-1 protein). Cox univariate regression analysis using EGFR as a continuous variable showed that EGFR levels are directly associated with the risk of death (chi 2 = 14.56, P-value = 0.0001) and relapse (chi 2 = 7.77, P-value = 0.0053). A significant relationship between EGFR status and survival was observed at the different arbitrary cut-off values chosen (8, 16 and 20 fmol mg-1 protein). The cut-off value of 20 fmol mg-1 protein was the best prognostic discriminator. In fact, the 5 year survival was 81% for patients with EGFR- tumours compared with 25% for patients with EGFR+ tumours (P < 0.0001). The 5 year relapse-free survival was 77% for patients with EGFR- tumours compared with 24% for patients with EGFR+ tumours (P < 0.010). When clinicopathological parameters and EGFR status were examined in the multivariate analysis, T classification and EGFR status retained an independent prognostic value. In this study we demonstrated that high EGFR levels single out patients with poor prognosis in laryngeal cancer.
Lingua originaleEnglish
pagine (da-a)1253-1257
Numero di pagine5
RivistaBritish Journal of Cancer
Stato di pubblicazionePubblicato - 1996

Keywords

  • head and neck cancer

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