TY - JOUR
T1 - Prognostic role of standard uptake value according to pathologic features of lung adenocarcinoma
AU - Bertoglio, Pietro
AU - Ventura, Luigi
AU - Aprile, Vittorio
AU - Cattoni, Maria Angela
AU - Nachira, Dania
AU - Lococo, Filippo
AU - Rodriguez Perez, Maria
AU - Guerrera, Francesco
AU - Minervini, Fabrizio
AU - Gnetti, Letizia
AU - Bacchin, Diana
AU - Franzi, Francesca
AU - Querzoli, Giulia
AU - Rindi, Guido
AU - Bellafiore, Salvatore
AU - Femia, Federico
AU - Viti, Andrea
AU - Kestenholz, Peter
AU - Ruffini, Enrico
AU - Paci, Massimiliano
AU - Margaritora, Stefano
AU - Imperatori, Andrea Selenito
AU - Lucchi, Marco
AU - Carbognani, Paolo
AU - Terzi, Alberto Claudio
PY - 2022
Y1 - 2022
N2 - Objective: To evaluate the influence of lung adenocarcinoma second predominant pattern on the maximal standard uptake value (SUVmax) and its prognostic effect in different histologic groups. Methods: We retrospectively collected surgically resected pathologic stage I and II lung adenocarcinoma from nine European institutions. Only patients who underwent preoperative PET-CT and with available information regarding SUVmax of T (SUVmaxT) and N1 (SUVmaxN1) component were included. Results: We enrolled 344 patients with lung adenocarcinoma. SUVmaxT did not show any significant relation according to the second predominant pattern (p = 0.139); this relationship remained nonsignificant in patients with similar predominant pattern. SUVmaxT influenced the disease-free survival in the whole cohort (p = 0.002) and in low- and intermediate-grade predominant pattern groups (p = 0.040 and p = 0.008, respectively). In the high-grade predominant pattern cohort and in the pathologic N1 cases, SUVmaxT lost its prognostic power. SUVmaxN1 did not show any significant correlation with predominant and second predominant patterns and did not have any prognostic impact on DFS. Conclusions: SUVmaxT is influenced only by the adenocarcinoma predominant pattern, but not by second predominant pattern. Concurrently, in high-grade predominant pattern and pN1 group the prognostic power of SUVmaxT becomes nonsignificant.
AB - Objective: To evaluate the influence of lung adenocarcinoma second predominant pattern on the maximal standard uptake value (SUVmax) and its prognostic effect in different histologic groups. Methods: We retrospectively collected surgically resected pathologic stage I and II lung adenocarcinoma from nine European institutions. Only patients who underwent preoperative PET-CT and with available information regarding SUVmax of T (SUVmaxT) and N1 (SUVmaxN1) component were included. Results: We enrolled 344 patients with lung adenocarcinoma. SUVmaxT did not show any significant relation according to the second predominant pattern (p = 0.139); this relationship remained nonsignificant in patients with similar predominant pattern. SUVmaxT influenced the disease-free survival in the whole cohort (p = 0.002) and in low- and intermediate-grade predominant pattern groups (p = 0.040 and p = 0.008, respectively). In the high-grade predominant pattern cohort and in the pathologic N1 cases, SUVmaxT lost its prognostic power. SUVmaxN1 did not show any significant correlation with predominant and second predominant patterns and did not have any prognostic impact on DFS. Conclusions: SUVmaxT is influenced only by the adenocarcinoma predominant pattern, but not by second predominant pattern. Concurrently, in high-grade predominant pattern and pN1 group the prognostic power of SUVmaxT becomes nonsignificant.
KW - PET-CT
KW - lung cancer
KW - lung adenocarcinoma
KW - SUV
KW - PET-CT
KW - lung cancer
KW - lung adenocarcinoma
KW - SUV
UR - http://hdl.handle.net/10807/245997
U2 - 10.1177/03008916211018515
DO - 10.1177/03008916211018515
M3 - Article
SN - 2038-2529
VL - 108
SP - 461
EP - 469
JO - Tumori
JF - Tumori
ER -