Abstract
In this study, we investigated the prognostic value of metastasis tumor antigen 1 expression in 81 untreated patients with ovarian cancer. The expression of metastasis tumor antigen 1 was evaluated by immunohistochemistry, and staining was analyzed in relation to clinicopathologic variables, disease-free survival, and overall survival. High expression of metastasis tumor antigen 1 was found to be associated with advanced stage (I/II versus III/IV, P = .02) and with worse response to first-line treatment (P = .03). Cases with high metastasis tumor antigen 1 expression showed a lower disease-free survival compared with cases with low expression (P = .02). In multivariate analysis of disease-free survival, metastasis tumor antigen 1 overexpression retained an independent negative prognostic role (P = .04), when considered together with histotype, stage of disease, residual tumor at surgery, and chemosensitivity. The evaluation of the prognostic relevance of metastasis tumor antigen 1 in late-stage disease showed that overexpression was a prognostic factor for poor disease-free survival and overall survival in this subset of patients, in both univariate and multivariate models. These findings indicate that metastasis tumor antigen 1 overexpression can be used as a predictor of clinical outcome in patients with ovarian cancer and therefore may represent a new prognostic marker.
Lingua originale | English |
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pagine (da-a) | 282-288 |
Numero di pagine | 7 |
Rivista | Human Pathology |
Volume | 43 |
DOI | |
Stato di pubblicazione | Pubblicato - 2012 |
Keywords
- Adenocarcinoma
- Adult
- Aged
- Aged, 80 and over
- Female
- Histone Deacetylases
- Humans
- Middle Aged
- Neoplasm Staging
- Ovarian Neoplasms
- Repressor Proteins
- Survival Analysis
- Survival Rate
- Taiwan
- Tumor Markers, Biological