Prognostic role of metastasis tumor antigen 1 in patients with ovarian cancer: a clinical study

Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia, Daniela Gallo Guido, Mg Prisco, Ilaria De Stefano, Vg Vellone, L Tortorella, L Mereu

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

In this study, we investigated the prognostic value of metastasis tumor antigen 1 expression in 81 untreated patients with ovarian cancer. The expression of metastasis tumor antigen 1 was evaluated by immunohistochemistry, and staining was analyzed in relation to clinicopathologic variables, disease-free survival, and overall survival. High expression of metastasis tumor antigen 1 was found to be associated with advanced stage (I/II versus III/IV, P = .02) and with worse response to first-line treatment (P = .03). Cases with high metastasis tumor antigen 1 expression showed a lower disease-free survival compared with cases with low expression (P = .02). In multivariate analysis of disease-free survival, metastasis tumor antigen 1 overexpression retained an independent negative prognostic role (P = .04), when considered together with histotype, stage of disease, residual tumor at surgery, and chemosensitivity. The evaluation of the prognostic relevance of metastasis tumor antigen 1 in late-stage disease showed that overexpression was a prognostic factor for poor disease-free survival and overall survival in this subset of patients, in both univariate and multivariate models. These findings indicate that metastasis tumor antigen 1 overexpression can be used as a predictor of clinical outcome in patients with ovarian cancer and therefore may represent a new prognostic marker.
Lingua originaleEnglish
pagine (da-a)282-288
Numero di pagine7
RivistaHuman Pathology
Volume43
DOI
Stato di pubblicazionePubblicato - 2012

Keywords

  • Adenocarcinoma
  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Histone Deacetylases
  • Humans
  • Middle Aged
  • Neoplasm Staging
  • Ovarian Neoplasms
  • Repressor Proteins
  • Survival Analysis
  • Survival Rate
  • Taiwan
  • Tumor Markers, Biological

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