TY - JOUR
T1 - Prognostic role of artificial intelligence among patients with hepatocellular cancer: A systematic review
AU - Lai, Quirino
AU - Spoletini, Gabriele
AU - Mennini, Gianluca
AU - Laureiro, Zoe Larghi
AU - Tsilimigras, Diamantis I
AU - Pawlik, Timothy Michael
AU - Rossi, Massimo
PY - 2020
Y1 - 2020
N2 - BACKGROUND Prediction of survival after the treatment of hepatocellular carcinoma (HCC) has been widely investigated, yet remains inadequate. The application of artificial intelligence (AI) is emerging as a valid adjunct to traditional statistics due to the ability to process vast amounts of data and find hidden interconnections between variables. AI and deep learning are increasingly employed in several topics of liver cancer research, including diagnosis, pathology, and prognosis. AIM To assess the role of AI in the prediction of survival following HCC treatment. METHODS A web-based literature search was performed according to the Preferred Reporting Items for Systemic Reviews and Meta-Analysis guidelines using the keywords “artificial intelligence”, “deep learning” and “hepatocellular carcinoma” (and synonyms). The specific research question was formulated following the patient (patients with HCC), intervention (evaluation of HCC treatment using AI), comparison (evaluation without using AI), and outcome (patient death and/or tumor recurrence) structure. English language articles were retrieved, screened, and reviewed by the authors. The quality of the papers was assessed using the Risk of Bias In Non-randomized Studies of Interventions tool. Data were extracted and collected in a database. RESULTS Among the 598 articles screened, nine papers met the inclusion criteria, six of which had low-risk rates of bias. Eight articles were published in the last decade; all came from eastern countries. Patient sample size was extremely heterogenous (n = 11-22926). AI methodologies employed included artificial neural networks (ANN) in six studies, as well as support vector machine, artificial plant optimization, and peritumoral radiomics in the remaining three studies. All the studies testing the role of ANN compared the performance of ANN with traditional statistics. Training cohorts were used to train the neural networks that were then applied to validation cohorts. In all cases, the AI models demonstrated superior predictive performance compared with traditional statistics with significantly improved areas under the curve. CONCLUSION AI applied to survival prediction after HCC treatment provided enhanced accuracy compared with conventional linear systems of analysis. Improved transferability and reproducibility will facilitate the widespread use of AI methodologies.
AB - BACKGROUND Prediction of survival after the treatment of hepatocellular carcinoma (HCC) has been widely investigated, yet remains inadequate. The application of artificial intelligence (AI) is emerging as a valid adjunct to traditional statistics due to the ability to process vast amounts of data and find hidden interconnections between variables. AI and deep learning are increasingly employed in several topics of liver cancer research, including diagnosis, pathology, and prognosis. AIM To assess the role of AI in the prediction of survival following HCC treatment. METHODS A web-based literature search was performed according to the Preferred Reporting Items for Systemic Reviews and Meta-Analysis guidelines using the keywords “artificial intelligence”, “deep learning” and “hepatocellular carcinoma” (and synonyms). The specific research question was formulated following the patient (patients with HCC), intervention (evaluation of HCC treatment using AI), comparison (evaluation without using AI), and outcome (patient death and/or tumor recurrence) structure. English language articles were retrieved, screened, and reviewed by the authors. The quality of the papers was assessed using the Risk of Bias In Non-randomized Studies of Interventions tool. Data were extracted and collected in a database. RESULTS Among the 598 articles screened, nine papers met the inclusion criteria, six of which had low-risk rates of bias. Eight articles were published in the last decade; all came from eastern countries. Patient sample size was extremely heterogenous (n = 11-22926). AI methodologies employed included artificial neural networks (ANN) in six studies, as well as support vector machine, artificial plant optimization, and peritumoral radiomics in the remaining three studies. All the studies testing the role of ANN compared the performance of ANN with traditional statistics. Training cohorts were used to train the neural networks that were then applied to validation cohorts. In all cases, the AI models demonstrated superior predictive performance compared with traditional statistics with significantly improved areas under the curve. CONCLUSION AI applied to survival prediction after HCC treatment provided enhanced accuracy compared with conventional linear systems of analysis. Improved transferability and reproducibility will facilitate the widespread use of AI methodologies.
KW - Artificial neuronal network
KW - Deep learning
KW - Resection
KW - Liver transplantation
KW - Recurrence
KW - Hepatocellular cancer
KW - Artificial neuronal network
KW - Deep learning
KW - Resection
KW - Liver transplantation
KW - Recurrence
KW - Hepatocellular cancer
UR - http://hdl.handle.net/10807/305358
U2 - 10.3748/wjg.v26.i42.6679
DO - 10.3748/wjg.v26.i42.6679
M3 - Article
SN - 1007-9327
VL - 26
SP - 6679
EP - 6688
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
ER -