Abstract
Objective: To evaluate the prognostic significance of oxidative stress (OS) and antioxidant defence status measurement in patients with chronic lymphocytic leukaemia (CLL). Methods: d-ROMs test and BAP test were evaluated at diagnosis of 165 patients with CLL and correlated with clinical-biological features and prognosis. Results: An increased oxidative damage (d-ROMs test) and a reduced antioxidant potential (BAP test) were found in CLL patients than normal controls (P<.0001). CLL patients with higher d-ROMs values had higher number of circulating white blood cells and lymphocytes, and higher values of β2-microglobulin. Higher d-ROMs values were found in female (P=.0003), in patients with unmutated IgVH (P=.04), unfavourable cytogenetics (P=.002) and more advanced clinical stage (P=.002). Higher BAP test values were found in patients expressing CD49d (P=.01) and with more advanced clinical stage (P=.004). At a median follow-up of 48 months, CLL patients with d-ROMs â¥418 CARR U were found to have a shorter time to first treatment (TFT) (P=.0002), and a reduced survival (P=.006) than others. CLL patients with BAP test values â¥2155 μmol/L had a shorter TFT (P=.008) and a shorter survival (P=.003). Conclusions: OS can affect CLL patients by concomitantly increasing reactive oxygen metabolites production and decreasing antioxidant defences.
Lingua originale | English |
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pagine (da-a) | 306-314 |
Numero di pagine | 9 |
Rivista | European Journal of Haematology |
Volume | 99 |
DOI | |
Stato di pubblicazione | Pubblicato - 2017 |
Keywords
- BAP test
- Hematology
- chronic lymphocytic leukaemia
- d-ROMs
- oxidative stress
- prognosis