Prognostic relevance of MLH1 and MSH2 mutations in hereditary non-polyposis colorectal cancer patients

Emanuela Lucci Cordisco, Maurizio Genuardi, A Russo, P Sala, P Alberici, I Gazzoli, P Radice, C Montefusco, M Torrini, C Mareni, M Fornasarig, M Santarosa, A Viel, P Benatti, M Pedroni, M De Leon, L Messerini, V Stigliano, A Cama, M CuriaL De Lellis, S Signoroni, M Pierotti, L. Bertario

Risultato della ricerca: Contributo in rivistaArticolo in rivista

9 Citazioni (Scopus)

Abstract

Aims and background. Colorectal carcinoma patients from hereditary non-polyposis colorectal cancer families are suggested to have a better prognosis than sporadic colorectal carcinoma cases. Since the majority of hereditary non-polyposis colorectal cancer-related colorectal carcinomas are characterized by microsatellite instability due to germline mutations in DNA mismatch repair genes, this is consistent with the prolonged survival observed in sporadic microsatellite instability-positive colorectal carcinoma compared to microsatellite stable cases. However, a fraction of colorectal carcinoma cases belongs to families that, despite fulfilling the clinical criteria for hereditary non-polyposis colorectal cancer, do not carry mismatch repair gene mutations. Our aim was to verify to what extent the genotypic heterogeneity influences the prognosis of hereditary non-polyposis colorectal cancer patients. Methods. A survival analysis was performed on 526 colorectal carcinoma cases from 204 Amsterdam Criteria-positive hereditary non-polyposis colorectal cancer families. Enrolled cases were classified as MLITH-positive, MSH2-positive and mutation-negative, according to the results of genetic testing in each family. Results. Five-year survival rates were 0.73 (95% Cl, 0.66-0.80), 0.75 (95% CI, 0.66-0.84) and 0.62 (95% Cl, 0.55-0.68) for MLH1-positive, MSH2-positive and mutation-negative groups, respectively (logrank test, P= 0.01). Hazard ratio, computed using Cox regression analysis and adjusted for age, sex, tumor site and stage, was 0.71 (95% Cl, 0.51-0.981 for the mutation-positive compared to the mutation-negative group. Moreover, in the latter group, patients with microsatellite instability-positive colorectal carcinomas showed a better outcome than microsatellite stable cases (5-year survival rates, 0.81 and 0.60, respectively; logrank test, P = 0.006). Conclusions. Our results suggest that the prognosis of hereditary non-polyposis colorectal cancer-related colorectal carcinoma patients depends on the associated constitutional mismatch repair genotype.
Lingua originaleEnglish
pagine (da-a)731-738
Numero di pagine8
RivistaTumori
Volume95
Stato di pubblicazionePubblicato - 2009

Keywords

  • ADJUVANT CHEMOTHERAPY
  • COLON-CANCER
  • CRITERIA
  • FAMILIES
  • FEATURES
  • HNPCC
  • LYNCH-SYNDROME
  • MICROSATELLITE-INSTABILITY STATUS
  • SURVIVAL
  • TUMOR-INFILTRATING LYMPHOCYTES

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