PROGNOSTIC RELEVANCE OF CLINICAL-PHARMACOLOGY OF ANTILEUKEMIC DRUGS

Riccardo Riccardi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

5 Citazioni (Scopus)

Abstract

Response to treatment is the most important prognostic factor in children undergoing treatment for acute lymphoblastic leukemia. Factors that interfere with the pharmacokinetic determinants of anti-leukemic compounds may cause a decreased activity of one or more of the drugs included in the treatment protocol. Noncompliance with the prescribed treatment, individual pharmacokinetic differences, interference with oral drug absorption, and different guidelines for dose reduction related to toxicity are some of the factors responsible for a decreased or variable antileukemic activity which may influence treatment results.
Lingua originaleEnglish
pagine (da-a)173-176
Numero di pagine4
RivistaMedical and Pediatric Oncology
Volume14
DOI
Stato di pubblicazionePubblicato - 1986

Keywords

  • acute leukemia
  • clinical pharmacology
  • prognosis

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