Prognostic relevance of c-Myc and BMI1 expression in patients with glioblastoma

Maurizio Martini, Nicola Montano, Francesco Pierconti, Roberto Pallini, Luigi Maria Larocca, Tonia Cenci, Quintino Giorgio D'Alessandris, Federico Bianchi, Maria Laura Falchetti, Daniela Annibali, Mauro Savino, Sergio Nasi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

27 Citazioni (Scopus)

Abstract

Although the c-Myc oncogene is frequently deregulated in human cancer, its involvement in the pathogenesis of glioblastoma is not clear. We conducted immunohistochemical analysis of the expression of c-Myc, polycomb ring finger oncogene (BMI1), and acetylation of the lysine 9 (H3K9Ac) of histone 3 in 48 patients with glioblastoma who underwent surgery followed by radiotherapy and temozolomide treatment. The expression of c-Myc, BMI1, and H3K9ac was correlated with clinical characteristics and outcome. We found that overexpression of c-Myc was significantly associated with that of BMI1 (P = .009), and that patients who harbored glioblastomas overexpressing c-Myc and BMI1 showed significantly longer overall survival (P < .0001 and P = .0009, respectively). Our results provide the first evidence of the prognostic value of c-Myc and associated genes in patients with glioblastoma. The favorable effect of c-Myc and BMI1 expression on survival is likely mediated by the sensitization of cancer cells to radiotherapy and temozolomide through the activation of apoptotic pathways
Lingua originaleEnglish
pagine (da-a)390-396
Numero di pagine7
RivistaAmerican Journal of Clinical Pathology
Volume138
DOI
Stato di pubblicazionePubblicato - 2012

Keywords

  • Brain Neoplasms
  • Combined Modality Therapy

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