TY - JOUR
T1 - Prognostic relevance of c-Myc and BMI1 expression in patients with glioblastoma
AU - Cenci, Tonia
AU - Martini, Maurizio
AU - Montano, Nicola
AU - D'Alessandris, Quintino Giorgio
AU - Falchetti, Maria Laura
AU - Annibali, Daniela
AU - Savino, Mauro
AU - Bianchi, Federico
AU - Pierconti, Francesco
AU - Nasi, Sergio
AU - Pallini, Roberto
AU - Larocca, Luigi Maria
PY - 2012
Y1 - 2012
N2 - Although the c-Myc oncogene is frequently deregulated in human cancer, its involvement in the pathogenesis of glioblastoma is not clear. We conducted immunohistochemical analysis of the expression of c-Myc, polycomb ring finger oncogene (BMI1), and acetylation of the lysine 9 (H3K9Ac) of histone 3 in 48 patients with glioblastoma who underwent surgery followed by radiotherapy and temozolomide treatment. The expression of c-Myc, BMI1, and H3K9ac was correlated with clinical characteristics and outcome. We found that overexpression of c-Myc was significantly associated with that of BMI1 (P = .009), and that patients who harbored glioblastomas overexpressing c-Myc and BMI1 showed significantly longer overall survival (P < .0001 and P = .0009, respectively). Our results provide the first evidence of the prognostic value of c-Myc and associated genes in patients with glioblastoma. The favorable effect of c-Myc and BMI1 expression on survival is likely mediated by the sensitization of cancer cells to radiotherapy and temozolomide through the activation of apoptotic pathways
AB - Although the c-Myc oncogene is frequently deregulated in human cancer, its involvement in the pathogenesis of glioblastoma is not clear. We conducted immunohistochemical analysis of the expression of c-Myc, polycomb ring finger oncogene (BMI1), and acetylation of the lysine 9 (H3K9Ac) of histone 3 in 48 patients with glioblastoma who underwent surgery followed by radiotherapy and temozolomide treatment. The expression of c-Myc, BMI1, and H3K9ac was correlated with clinical characteristics and outcome. We found that overexpression of c-Myc was significantly associated with that of BMI1 (P = .009), and that patients who harbored glioblastomas overexpressing c-Myc and BMI1 showed significantly longer overall survival (P < .0001 and P = .0009, respectively). Our results provide the first evidence of the prognostic value of c-Myc and associated genes in patients with glioblastoma. The favorable effect of c-Myc and BMI1 expression on survival is likely mediated by the sensitization of cancer cells to radiotherapy and temozolomide through the activation of apoptotic pathways
KW - Brain Neoplasms
KW - Combined Modality Therapy
KW - Brain Neoplasms
KW - Combined Modality Therapy
UR - http://hdl.handle.net/10807/79885
U2 - 10.1309/AJCPRXHNJQLO09QA
DO - 10.1309/AJCPRXHNJQLO09QA
M3 - Article
SN - 0002-9173
VL - 138
SP - 390
EP - 396
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
ER -
