Abstract
BACKGROUND AND OBJECTIVES: The clinical characteristics and patient outcome of a
group of patients treated for differentiated thyroid carcinoma (DTC) were
analyzed in order to assess the relative influence of different prognostic
factors.
MATERIALS AND METHODS: We retrospectively reviewed data about sex, age, size and
histologic behavior of the tumor, extrathyroid extension of the tumor, lymph node
status, distant metastasis at diagnosis, surgical procedures, and overall
survival from 234 patients treated for DTC. Data were submitted to a statistical
analysis.
RESULTS: Using a univariate analysis, we found that survival rates were
significantly influenced by age (P = 0.0001), size (P = 0.018), extrathyroidal
extension (P = 0.000001), lymph node involvement (P = 0.03), and distant
metastases (P = 0.049). Age and size were independent prognostic factors at
multivariate analysis (t = 2.694 and t = 2.443, respectively).
CONCLUSIONS: On the basis of our results and of a review of the literature, we
conclude that total thyroidectomy is the treatment of choice in DTC, except for
small (<1 cm) papillary carcinoma, that could be treated by lobectomy plus
isthmectomy, while lymphadenectomy is indicated only in case of macroscopic
involvement.
Lingua originale | English |
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pagine (da-a) | 237-241 |
Numero di pagine | 5 |
Rivista | Journal of Surgical Oncology |
Volume | 68 |
DOI | |
Stato di pubblicazione | Pubblicato - 1998 |
Keywords
- Lymph Node Excision
- Multivariate Analysis
- Prognosis
- Proportional Hazards Models
- Retrospective Studies
- Sex Factors
- Survival Rate
- Thyroid Neoplasms
- Thyroid carcinoma
- Thyroidectomy
- Treatment Outcome