TY - JOUR
T1 - Prognostic factors affecting survival after pulmonary resection of metastatic renal cell carcinoma: A multicenter experience
AU - Meacci, Elisa
AU - Nachira, Dania
AU - Zanfrini, Edoardo
AU - Evangelista, Jessica
AU - Triumbari, Elizabeth Katherine Anna
AU - Congedo, Maria Teresa
AU - Petracca Ciavarella, Leonardo
AU - Chiappetta, Marco
AU - Vita, Maria Letizia
AU - Schinzari, Giovanni
AU - Rossi, Ernesto
AU - Tortora, Giampaolo
AU - Lucchi, Marco
AU - Ambrogi, Marcello
AU - Calabrò, Fabrizia
AU - Petrella, Francesco
AU - Spaggiari, Lorenzo
AU - Mammana, Marco
AU - Madrid, Andrea Lloret
AU - Rea, Federico
AU - Tabacco, Diomira
AU - Margaritora, Stefano
PY - 2021
Y1 - 2021
N2 - In this paper we aimed to address the role of pulmonary metastasectomy (PM) in patients affected by Lung Metastases (LM) from Renal Cell Carcinoma (RCC) and to analyse prognostic factors affecting overall survival (OS), disease-free interval (DFI) between primary RCC and first LM, and disease-free survival (DFS) after PM and before lung recurrence. Medical records of 210 patients who underwent PM from RCC in 4 Italian Thoracic Centres, from January 2000 to September 2019, were collected and analysed. All patients underwent RCC resection before lung surgery. The main RCC histology was clear cells (188, 89.5%). The 5-and 10-year OS from the first lung operation were 60% and 34%, respectively. LM synchronous with RCC (p = 0.01) and (Karnofsky Performance Status Scale) KPSS < 80% (p < 0.001) negatively influenced OS. Five-and 10-year DFI were 54% and 28%, respectively. The main factors negatively influencing DFI were: male gender (p = 0.039), KPSS < 80% (p = 0.009) and lactate dehydrogenase > 1.5 times 140 U/L (p = 0.001). Five-and 10-year disease-free survival were 54% and 28%, respectively; multiple LM (p = 0.036), KPSS < 80% (p = 0.001) and histology of RCC other than clear cells negatively influenced disease-free survival. Conclusions: patients with KPSS > 80%, single metachronous LM with a long DFI from RCC diagnosis, and clear cell histology, benefit from pulmonary metastasectomy.
AB - In this paper we aimed to address the role of pulmonary metastasectomy (PM) in patients affected by Lung Metastases (LM) from Renal Cell Carcinoma (RCC) and to analyse prognostic factors affecting overall survival (OS), disease-free interval (DFI) between primary RCC and first LM, and disease-free survival (DFS) after PM and before lung recurrence. Medical records of 210 patients who underwent PM from RCC in 4 Italian Thoracic Centres, from January 2000 to September 2019, were collected and analysed. All patients underwent RCC resection before lung surgery. The main RCC histology was clear cells (188, 89.5%). The 5-and 10-year OS from the first lung operation were 60% and 34%, respectively. LM synchronous with RCC (p = 0.01) and (Karnofsky Performance Status Scale) KPSS < 80% (p < 0.001) negatively influenced OS. Five-and 10-year DFI were 54% and 28%, respectively. The main factors negatively influencing DFI were: male gender (p = 0.039), KPSS < 80% (p = 0.009) and lactate dehydrogenase > 1.5 times 140 U/L (p = 0.001). Five-and 10-year disease-free survival were 54% and 28%, respectively; multiple LM (p = 0.036), KPSS < 80% (p = 0.001) and histology of RCC other than clear cells negatively influenced disease-free survival. Conclusions: patients with KPSS > 80%, single metachronous LM with a long DFI from RCC diagnosis, and clear cell histology, benefit from pulmonary metastasectomy.
KW - Lung metastases
KW - Metastasectomy
KW - Metastatic renal cell carcinoma
KW - Renal cell carcinoma
KW - Lung metastases
KW - Metastasectomy
KW - Metastatic renal cell carcinoma
KW - Renal cell carcinoma
UR - http://hdl.handle.net/10807/201679
U2 - 10.3390/cancers13133258
DO - 10.3390/cancers13133258
M3 - Article
SN - 2072-6694
VL - 13
SP - 3258-N/A
JO - Cancers
JF - Cancers
ER -