TY - JOUR
T1 - Profiling severe asthma: Any relevance for age? An analysis from Severe Asthma Network Italy (SANI) cohort
AU - Caminati, Marco
AU - Marcon, Alessandro
AU - Vaia, Rachele
AU - Senna, Gianenrico
AU - Maule, Matteo
AU - Marchetti, Pierpaolo
AU - Miotti, Jessica
AU - Argentino, Giuseppe
AU - Blasi, Francesco
AU - Canonica, Giorgio W.
AU - Heffler, Enrico M.
AU - Paggiaro, Pierluigi
AU - Vianello, Andrea
AU - Guarnieri, Gabriella
AU - Brussino, Luisa
AU - Calabrese, Cecilia
AU - Camiciottoli, Gianna
AU - Carpagnano, Giovanna E.
AU - Centanni, Stefano
AU - Corsico, Angelo G.
AU - Costantino, Maria T.
AU - Crimi, Claudia
AU - D'Adda, Alice
AU - D'Alo, Simona
AU - D'Amato, Maria
AU - Del Giacco, Stefano
AU - Di Marco, Fabiano
AU - Facciolongo, Nicola C.
AU - Latorre, Manuela
AU - Nettis, Eustachio
AU - Nucera, Eleonora
AU - Passalacqua, Giovanni
AU - Pelaia, Girolamo
AU - Pini, Laura
AU - Ricciardi, Luisa
AU - Richeldi, Luca
AU - Ridolo, Erminia
AU - Santus, Pierachille
AU - Scichilone, Nicola
AU - Scioscia, Giulia
AU - Spadaro, Giuseppe
AU - Spanevello, Antonio
AU - Tarsia, Paolo
PY - 2024
Y1 - 2024
N2 - Background: Aging implies changes in terms of lung function, immune system, and respiratory and extra-respiratory comorbidities. Few studies have specifically addressed the relevance of age on severe asthma burden and control. We aimed to evaluate whether age acts as an independent determinant of asthma severity, in terms of clinical, functional, and inflammatory profile, and to explore potential cofactors that contribute to a more difficult disease control in different age groups. Methods: Patients from Severe Asthma Network Italy (SANI) registry were retrospectively divided in subgroups according to their age. Cutoffs for age were established according to quartiles in order to obtain a comparable number of patients for each group, and then rounded for the sake of simplicity. Results: Overall, 1805 severe asthma patients were analyzed. Lung function represented the most important age-related variable. On the opposite the level of asthma control was not differently distributed among age ranges. In young people the presence of atopy-related comorbidities (allergic rhinitis, atopic dermatitis) predominated, whilst systemic-metabolic and degenerative comorbidities such as diabetes, cardiovascular diseases, anxious-depressive syndrome, and osteoporosis prevailed in elderly. Bronchiectasis and sleep disturbances were significantly associated with age. Conclusions: Despite that it cannot be considered a treatable trait, our study suggests that age should be evaluated within a personalized approach to severe asthma patients, in order to provide a better clinical profiling and a more tailored treatment strategy.
AB - Background: Aging implies changes in terms of lung function, immune system, and respiratory and extra-respiratory comorbidities. Few studies have specifically addressed the relevance of age on severe asthma burden and control. We aimed to evaluate whether age acts as an independent determinant of asthma severity, in terms of clinical, functional, and inflammatory profile, and to explore potential cofactors that contribute to a more difficult disease control in different age groups. Methods: Patients from Severe Asthma Network Italy (SANI) registry were retrospectively divided in subgroups according to their age. Cutoffs for age were established according to quartiles in order to obtain a comparable number of patients for each group, and then rounded for the sake of simplicity. Results: Overall, 1805 severe asthma patients were analyzed. Lung function represented the most important age-related variable. On the opposite the level of asthma control was not differently distributed among age ranges. In young people the presence of atopy-related comorbidities (allergic rhinitis, atopic dermatitis) predominated, whilst systemic-metabolic and degenerative comorbidities such as diabetes, cardiovascular diseases, anxious-depressive syndrome, and osteoporosis prevailed in elderly. Bronchiectasis and sleep disturbances were significantly associated with age. Conclusions: Despite that it cannot be considered a treatable trait, our study suggests that age should be evaluated within a personalized approach to severe asthma patients, in order to provide a better clinical profiling and a more tailored treatment strategy.
KW - Aging
KW - Asthma control
KW - Comorbidities
KW - Lung function
KW - Severe asthma
KW - Aging
KW - Asthma control
KW - Comorbidities
KW - Lung function
KW - Severe asthma
UR - http://hdl.handle.net/10807/289159
U2 - 10.1016/j.waojou.2024.100941
DO - 10.1016/j.waojou.2024.100941
M3 - Article
SN - 1939-4551
VL - 17
SP - 2
EP - 14
JO - THE WORLD ALLERGY ORGANIZATION JOURNAL
JF - THE WORLD ALLERGY ORGANIZATION JOURNAL
ER -