Probiotics in antibiotic-associated diarrhoea

Filippo Cremonini, Simona Di Caro, L Santarelli, M Gabrielli, Marcello Candelli, Enrico Celestino Nista, Andrea Lupascu, Giovanni Battista Gasbarrini, Antonio Gasbarrini

Risultato della ricerca: Contributo in rivistaArticolo in rivista


Antibiotic-associated diarrhoea is a common event. In some cases, it could represent a life-threatening event. Clostridium difficile colitis is a further distinct complication of antibiotic administration. Treatment options for antibiotic-associated diarrhoea and Clostridium difficile colitis include supplementation with several types of probiotics, as overviewed in this paper. Three randomised, double-blind, controlled clinical trials show a therapeutic effect of Saccharomyces boulardii in antibiotic-associated diarrhoea. The efficacy of Lactobacillus acidophilus and bulgaricus has also been ascertained in two double-blind controlled studies. Other studies focusing on Lactobacillus as a new preventive agent for antibiotic-associated diarrhoea are not double-blind. Among these, a positive effect of Lactobacillus rhamnosus GG, Bifidobacterium longum and Enterococcus faecium SF68 has been reported. Effectiveness of probiotics in antibiotic-associated diarrhoea has, therefore, a consistent scientific rationale, however few studies have performed an assessment of bacterial recovery in stools, and this approach may be helpful in deciding a more rigorous dose standardisation
Lingua originaleEnglish
pagine (da-a)78-80
Numero di pagine3
RivistaDigestive and Liver Disease
Stato di pubblicazionePubblicato - 2002


  • probiotics


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