Probiotics and time to achieve full enteral feeding in human milk-fed and formula-fed preterm infants: Systematic review and meta-analysis

Luca Maggio, Giovanni Barone, Arianna Aceti, Davide Gori, Maria Pia Fantini, Flavia Indrio, Fabio Meneghin, Gianvincenzo Zuccotti, Luigi Corvaglia

Risultato della ricerca: Contributo in rivistaArticolo in rivista

19 Citazioni (Scopus)

Abstract

Probiotics have been linked to a reduction in the incidence of necrotizing enterocolitis and late-onset sepsis in preterm infants. Recently, probiotics have also proved to reduce time to achieve full enteral feeding (FEF). However, the relationship between FEF achievement and type of feeding in infants treated with probiotics has not been explored yet. The aim of this systematic review and meta-analysis was to evaluate the effect of probiotics in reducing time to achieve FEF in preterm infants, according to type of feeding (exclusive human milk (HM) vs. formula). Randomized-controlled trials involving preterm infants receiving probiotics, and reporting on time to reach FEF were included in the systematic review. Trials reporting on outcome according to type of feeding (exclusive HM vs. formula) were included in the meta-analysis. Fixed-effect or random-effects models were used as appropriate. Results were expressed as mean difference (MD) with 95% confidence interval (CI). Twenty-five studies were included in the systematic review. In the five studies recruiting exclusively HM-fed preterm infants, those treated with probiotics reached FEF approximately 3 days before controls (MD –3.15 days (95% CI –5.25/–1.05), p = 0.003). None of the two studies reporting on exclusively formula-fed infants showed any difference between infants receiving probiotics and controls in terms of FEF achievement. The limited number of included studies did not allow testing for other subgroup differences between HM and formula-fed infants. However, if confirmed in further studies, the 3-days reduction in time to achieve FEF in exclusively HM-fed preterm infants might have significant implications for their clinical management.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaNutrients
Volume8
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • Child Development
  • Full enteral feeding
  • Human milk
  • Humans
  • Infant Formula
  • Infant Nutritional Physiological Phenomena
  • Infant, Newborn
  • Infant, Premature
  • Infant, Premature, Diseases
  • Milk, Human
  • Parenteral Nutrition
  • Preterm infants
  • Probiotics
  • Randomized Controlled Trials as Topic
  • Reproducibility of Results
  • Systematic review
  • Time Factors

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