Probiotic multistrain treatment may eradicate Helicobacter pylori from the stomach of dyspeptics: a placebo-controlled pilot study

Cesare Hassan, R Rosania, Mf Minenna, F Giorgio, A Facciorusso, V De Francesco, C Panella, E. Ierardi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

19 Citazioni (Scopus)

Abstract

Probiotics survive in gastric environment competing with H. pylori. We studied probiotic "multistrain" administration in dyspeptics with H. pylori (placebo-controlled study). Forty patients with H. pylori (urea breath test - UBT - and IgG) were treated for 10 days with a mixture of 8 species of probiotics. Control group represented by 40 positive subjects received placebo. A second UBT and H. pylori stool antigen (HpSA) detection were performed after 1 month. Patients who remained infected were treated with triple therapy undergoing another UBT after 30 days. A second line therapy was administered in remaining positive patients. Statistics: Fisher's exact probability and Student's t tests. Thirteen out of 40 patients using probiotics became negative, while controls remained positive, irrespectively of the initial UBT delta value. No difference in the eradication rates between the two groups was found (68%-71%). After second line therapy two patients remained positive. An adequate supplementation with probiotics might eradicate H. pylori.
Lingua originaleEnglish
pagine (da-a)244-249
Numero di pagine6
RivistaINFLAMMATION & ALLERGY - DRUG TARGETS
Volume11
Stato di pubblicazionePubblicato - 2012
Pubblicato esternamenteYes

Keywords

  • Adult
  • Aged
  • Breath Tests
  • Double-Blind Method
  • Dyspepsia
  • Female
  • Helicobacter Infections
  • Helicobacter pylori
  • Humans
  • Male
  • Middle Aged
  • Pilot Projects
  • Probiotics
  • Treatment Outcome
  • Urea
  • Young Adult

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