TY - JOUR
T1 - Proactive enteral nutrition in moderately preterm small for gestational age infants: a randomized clinical trial.
AU - Zecca, Enrico
AU - Costa, Simonetta
AU - Barone, Giovanni
AU - Giordano, Lucia
AU - Zecca, Chiara
AU - Maggio, Luca
PY - 2014
Y1 - 2014
N2 - Objective To investigate the efficacy of a proactive feeding regimen (PFR) in reducing hospital length of stay in a
population of moderately preterm small for gestational age (SGA) infants.
Study design SGA infants (z-score < 1.28) of gestational age (GA) 32-36 weeks and birth weight (BW) >1499 g
were allocated at random to receive either a PFR, starting with 100 mL/kg/day and gradually increasing to 200 mL/
kg/day by day 4, or a standard feeding regimen, starting with 60 mL/kg/day and gradually increasing to 170 mL/kg/
day by day 9. All infants received human milk.
Results A total of 72 infants were randomized to the 2 groups, 36 to the PFR group (mean GA, 35.1 0.7 weeks;
mean BW, 1761 177 g) and 36 to the standard feeding regimen group (mean GA, 35.5 1.2 weeks; mean BW,
1754 212 g). Infants in the PFR group were discharged significantly earlier (mean, 9.8 3.1 days vs
11.9 4.7 days; P = .029). The need for intravenous fluids (2.8% vs 33.3%; P = .0013) and the incidence of hypoglycemia
(0 vs 33.3%; P = .00016) were significantly lower in the PFR group. Feeding intolerance and fecal calprotectin
levels did not differ between the 2 groups.
Conclusion A PFR in moderately preterm SGA infants is well tolerated and significantly reduces both the length of
stay and the risk of neonatal hypoglycemia.
AB - Objective To investigate the efficacy of a proactive feeding regimen (PFR) in reducing hospital length of stay in a
population of moderately preterm small for gestational age (SGA) infants.
Study design SGA infants (z-score < 1.28) of gestational age (GA) 32-36 weeks and birth weight (BW) >1499 g
were allocated at random to receive either a PFR, starting with 100 mL/kg/day and gradually increasing to 200 mL/
kg/day by day 4, or a standard feeding regimen, starting with 60 mL/kg/day and gradually increasing to 170 mL/kg/
day by day 9. All infants received human milk.
Results A total of 72 infants were randomized to the 2 groups, 36 to the PFR group (mean GA, 35.1 0.7 weeks;
mean BW, 1761 177 g) and 36 to the standard feeding regimen group (mean GA, 35.5 1.2 weeks; mean BW,
1754 212 g). Infants in the PFR group were discharged significantly earlier (mean, 9.8 3.1 days vs
11.9 4.7 days; P = .029). The need for intravenous fluids (2.8% vs 33.3%; P = .0013) and the incidence of hypoglycemia
(0 vs 33.3%; P = .00016) were significantly lower in the PFR group. Feeding intolerance and fecal calprotectin
levels did not differ between the 2 groups.
Conclusion A PFR in moderately preterm SGA infants is well tolerated and significantly reduces both the length of
stay and the risk of neonatal hypoglycemia.
KW - PRETERM INFANT, NUTRITION
KW - PRETERM INFANT, NUTRITION
UR - http://hdl.handle.net/10807/63708
U2 - 10.1016/j.jpeds.2014.08.065
DO - 10.1016/j.jpeds.2014.08.065
M3 - Article
SN - 0022-3476
VL - 165
SP - 1135-1139.e1
JO - THE JOURNAL OF PEDIATRICS
JF - THE JOURNAL OF PEDIATRICS
ER -