Abstract
We investigated whether primary progressive aphasias (PPA) reflect non-random degradation of linguistic dimensions that might be supported by different neural subsystems and to what extent this degradation contributes to the emergence of clinical entities: semantic (S), logopenic (L) and nonfluent (NF) aphasia; apraxia of speech was also considered if associated with language disorders (AOS/aph). Forty-two aphasic patients are reported. Two main definable patterns of linguistic deficits tended to emerge that corresponded with identifiable patterns of brain atrophy, and probably diseases: the S variant, which principally expresses the impact of a "deep" cognitive (semantic) disorder on language, and AOS/aph in which "peripheral" executive components play a significant role. By contrast, NF aphasia emerged as a heterogeneous variant due to disorganization of various dimensions within the linguistic domain, that assumes different patterns depending on the differential distribution of atrophy in the perisylvian regions.
Lingua originale | Inglese |
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pagine (da-a) | 57-65 |
Numero di pagine | 9 |
Rivista | Brain and Language |
Volume | 135 |
DOI | |
Stato di pubblicazione | Pubblicato - 2014 |
Keywords
- Agrammatism
- Alzheimer’s disease
- Apraxia of speech
- Corticobasal degeneration
- Phonological deficit
- Primary progressive aphasia
- Semantic deficit
- Semantic dementia