Primary cardiac synovial sarcoma: A review correlating outcomes with surgery and adjuvant therapy

Antonella Coli*, Alessandra Cassano, Mariangela Novello, Franco O. Ranelletti, Libero Lauriola

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo in rivista


Background: Cardiac synovial sarcoma (CSS) is an extremely rare malignant tumor with a severe prognosis, due to frequent relapses and metastases. To obtain useful information for treatment protocols, we analyzed survival and therapy data from the cases reported in the literature. Methods: A search of MEDLINE was performed throughout December 2018. Using key words relating to primary CSS, we collected from the literature a total of 97 cases, mainly consisting of single case reports. To identify predictors of overall survival, statistical analyses were performed on a selected cohort of 55 patients for whom relevant clinicopathological data were available, including surgery and adjuvant therapy. Results: The univariable analysis revealed that patients in their first three decades of life have better overall survival. The univariable analysis also showed that patients not receiving adjuvant chemotherapy are at increased risk of death. In the multivariable analysis, tumor resection and chemotherapy are factors significantly improving overall survival. Conclusion: The survival of patients with CSS is positively influenced by a young patient's age and greatly improved by the administration of chemotherapy, even in the absence of tumor resection.
Lingua originaleEnglish
pagine (da-a)1321-1327
Numero di pagine7
RivistaJournal of Cardiac Surgery
Stato di pubblicazionePubblicato - 2019


  • cardiac synovial sarcoma
  • chemotherapy
  • review
  • statistical analysis
  • surgery


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