Prevention of post-operative hyperalgesia in a heroin-addicted patient on methadone maintenance

Roberta Barelli, Gloria Morelli Sbarra, Fabio Sbaraglia, Luca Zappia, Marco Rossi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

4 Citazioni (Scopus)


What is known and objective: The exponential increase in chronic opioid consumers resulted in more challenges regarding post-operative pain management. Considering the usual hyperalgesic response to pain and the increased opioid-tolerance, a multidrug approach should be desirable. Case description: We described the strategy in pain management of a patient receiving methadone maintenance treatment, who underwent surgery associated with moderate post-operative pain. The combination of balanced general anaesthesia and intraoperative continuous low-dose infusion of ketamine assured an appropriate control of post-operative pain without increasing opioid consumption. Besides, it was not associated with psychomimetic effects. What is new and conclusion: Ketamine can effectively reduce opioid requirements in chronic opioid users on methadone maintenance therapy and should therefore be considered promptly as part of a multimodal perioperative analgesia management in this category of patients.
Lingua originaleEnglish
pagine (da-a)397-399
Numero di pagine3
RivistaJournal of Clinical Pharmacy and Therapeutics
Stato di pubblicazionePubblicato - 2019


  • Analgesics, Opioid
  • Heroin
  • Humans
  • Hyperalgesia
  • Ketamine
  • Male
  • Methadone
  • Middle Aged
  • Opioid-Related Disorders
  • Pain Management
  • Pain, Postoperative
  • Perioperative Care
  • Postoperative Period


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