Prevalence of thyroid carcinoma in toxic goiter

G. De Rosa, Gabriella De Rosa, A. Testa, Antonia Carla Testa, D. Giacomini, J. Liverotti, A. Verzi, Domenico D'Ugo, L. Mascellari, A. Picciocchi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

4 Citazioni (Scopus)

Abstract

The prevalence of thyroid carcinoma in a surgical series of 159 patients with toxic goiter, compared with a surgical series of 460 patients with non-toxic goiter, is reported. As regards the hyperthyroid group carcinoma was found in 8 patients (5.0%); specifically, a similar incidence occurred in nodular toxic goiter (NTG) (5 cases: 6.1%) and autonomously functioning single nodule (AFSN) (3 cases: 4.8%), whereas no malignancy was detected in patients with diffuse toxic goiter (DTG). In the euthyroid group, carcinoma was found in 56 patients (12.2%). The presence of carcinoma was unsuspected in all hyperthyroid patients and in 19 out of 56 euthyroid patients; the sex ratio indicated a strong female prevalence (F/M: 7/1); the age distribution did not differ from the whole thyrotoxic group. Pathology detected a papillary carcinoma in all patients, multicentric in one case. Follow-up ranged from 1 to 5 years; no recurrencies were evidenced. Our data agree with other recent reports about the coexistence of hyperthyroidism and thyroid carcinoma; still there are some controversies concerning the clinical significance of occult thyroid carcinoma, that apparently occurs with a similar rate in toxic goiter, in non-toxic goiter and in the general population.
Lingua originaleEnglish
pagine (da-a)169-173
Numero di pagine5
RivistaJOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
Volume13
Stato di pubblicazionePubblicato - 1994

Keywords

  • hyperthyroidism
  • thyroid cancer
  • thyroid carcinoma
  • thyrotoxicosis
  • toxic goiter

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