Prevalence of small intestinal bacterial overgrowth in Parkinson's disease

Antonio Gasbarrini, Maurizio Gabrielli, Emidio Scarpellini, Alfonso Fasano, P Bonazzi, E Bendia, Ec Lauritano, Mg Ceravolo, M Capecci, A Rita Bentivoglio, L Provinciali, Pa Tonali

Risultato della ricerca: Contributo in rivistaArticolo in rivista

94 Citazioni (Scopus)

Abstract

BACKGROUND: Parkinson's disease (PD) is associated with gastrointestinal motility abnormalities that could favor the occurrence of small intestinal bacterial overgrowth. The aim of the study was to assess the prevalence of small intestinal bacterial overgrowth in PD patients. METHODS: Consecutive PD patients were enrolled. The controls were subjects without PD. All patients and controls underwent the glucose breath test to assess small intestinal bacterial overgrowth. RESULTS: Forty-eight PD patients and 36 controls were enrolled. The prevalence of small intestinal bacterial overgrowth was significantly higher in PD patients than in controls (54.17% vs 8.33%; P < .0001; OR, 2.24; 95% CI, 3.50-48.24). Multivariate analysis showed Hoehn and Yahr stage (OR, 3.07; 95% CI, 1.14-8.27) and Unified PD Rating score (OR, 1.12; 95% CI, 1.02-1.23) were significantly associated with small intestinal bacterial overgrowth in PD patients. CONCLUSIONS: Small intestinal bacterial overgrowth is highly prevalent in PD. Gastrointestinal motility abnormalities might explain this association
Lingua originaleEnglish
pagine (da-a)889-892
Numero di pagine4
RivistaMovement Disorders
Volume26
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Aged
  • Bacterial Infections
  • Female
  • Humans
  • Intestinal Diseases
  • Intestine, Small
  • Male
  • Middle Aged
  • Parkinson Disease

Fingerprint

Entra nei temi di ricerca di 'Prevalence of small intestinal bacterial overgrowth in Parkinson's disease'. Insieme formano una fingerprint unica.

Cita questo