Prevalence of primary clarithromycin resistance in Helicobacter pylori strains over a 15 year period in Italy

V De Francesco; M Margiotta; A Zullo; Cesare Hassan; F Giorgio; O Burattini; G Stoppino; U Cea; A Pace; M Zotti; S Morini; C Panella; E. Ierardi

doi:10.1093/jac/dkm005

Prevalence of primary clarithromycin resistance in Helicobacter pylori strains over a 15 year period in Italy

V De Francesco, M Margiotta, A Zullo, Cesare Hassan, F Giorgio, O Burattini, G Stoppino, U Cea, A Pace, M Zotti, S Morini, C Panella, E. Ierardi

Risultato della ricerca: Contributo in rivista › Articolo in rivista

86 Citazioni (Scopus)

Abstract

The frequency of primary clarithromycin resistance in Helicobacter pylori strains is increasing worldwide, and its presence significantly reduces the treatment efficacy of infection. This study aimed to evaluate whether the progression of the prevalence of clarithromycin resistance over a 15 year period has increased and whether a possible change in the distribution of the three most frequent point mutations, which account for the large majority of clarithromycin resistance cases, has taken place.

Lingua originale	English
pagine (da-a)	783-785
Numero di pagine	3
Rivista	Journal of Antimicrobial Chemotherapy
Volume	59
DOI	https://doi.org/10.1093/jac/dkm005
Stato di pubblicazione	Pubblicato - 2007
Pubblicato esternamente	Sì

Keywords

Anti-Bacterial Agents
Clarithromycin
Drug Resistance, Bacterial
Female
Helicobacter Infections
Helicobacter pylori
Humans
Italy
Male
Microbial Sensitivity Tests
Point Mutation
Reverse Transcriptase Polymerase Chain Reaction
Sex Characteristics

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10.1093/jac/dkm005

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De Francesco, V., Margiotta, M., Zullo, A., Hassan, C., Giorgio, F., Burattini, O., Stoppino, G., Cea, U., Pace, A., Zotti, M., Morini, S., Panella, C., & Ierardi, E. (2007). Prevalence of primary clarithromycin resistance in Helicobacter pylori strains over a 15 year period in Italy. Journal of Antimicrobial Chemotherapy, 59, 783-785. https://doi.org/10.1093/jac/dkm005

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AU - De Francesco, V

AU - Margiotta, M

AU - Zullo, A

AU - Hassan, Cesare

AU - Giorgio, F

AU - Burattini, O

AU - Stoppino, G

AU - Cea, U

AU - Pace, A

AU - Zotti, M

AU - Morini, S

AU - Panella, C

AU - Ierardi, E.

PY - 2007

Y1 - 2007

N2 - The frequency of primary clarithromycin resistance in Helicobacter pylori strains is increasing worldwide, and its presence significantly reduces the treatment efficacy of infection. This study aimed to evaluate whether the progression of the prevalence of clarithromycin resistance over a 15 year period has increased and whether a possible change in the distribution of the three most frequent point mutations, which account for the large majority of clarithromycin resistance cases, has taken place.

AB - The frequency of primary clarithromycin resistance in Helicobacter pylori strains is increasing worldwide, and its presence significantly reduces the treatment efficacy of infection. This study aimed to evaluate whether the progression of the prevalence of clarithromycin resistance over a 15 year period has increased and whether a possible change in the distribution of the three most frequent point mutations, which account for the large majority of clarithromycin resistance cases, has taken place.

KW - Anti-Bacterial Agents

KW - Clarithromycin

KW - Drug Resistance, Bacterial

KW - Female

KW - Helicobacter Infections

KW - Helicobacter pylori

KW - Humans

KW - Italy

KW - Male

KW - Microbial Sensitivity Tests

KW - Point Mutation

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Sex Characteristics

KW - Anti-Bacterial Agents

KW - Clarithromycin

KW - Drug Resistance, Bacterial

KW - Female

KW - Helicobacter Infections

KW - Helicobacter pylori

KW - Humans

KW - Italy

KW - Male

KW - Microbial Sensitivity Tests

KW - Point Mutation

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Sex Characteristics

UR - http://hdl.handle.net/10807/34767

U2 - 10.1093/jac/dkm005

DO - 10.1093/jac/dkm005

M3 - Article

SN - 0305-7453

VL - 59

SP - 783

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JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

ER -

Prevalence of primary clarithromycin resistance in Helicobacter pylori strains over a 15 year period in Italy

Abstract

Keywords

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