Prevalence of interstitial pneumonia suggestive of COVID-19 at 18F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study

D. Albano; F. Bertagna; P. Alongi; S. Baldari; A. Baldoncini; M. Bartolomei; F. Boccaletto; M. Boero; E. Borsatti; A. Bruno; L. Burroni; F. Capoccetti; M. Castellani; A. R. Cervino; F. Chierichetti; A. Ciarmiello; A. Corso; A. Cuocolo; Rimini M. L. De; D. Deandreis; M. E. Dottorini; F. Esposito; M. Farsad; M. Gasparini; C. M. Grana; M. Gregianin; L. Guerra; F. Loreti; A. Lupi; G. Martino; E. Milan; S. Modoni; S. Morbelli; A. Muni; E. Nicolai; B. Palumbo; S. Papa; A. Papaleo; R. Pellerito; C. Poti; P. Romano; C. Rossetti; P. Rossini; G. Rubini; L. Ruffini; G. Sacchetti; G. Savelli; S. Schiavariello; R. Sciagra; R. Sciuto; E. Seregni; S. Sestini; M. Sicolo; A. Spanu; G. Storto; M. T. Balducci; G. Trifiro; A. Versari; A. Vignati; D. Volterrani; Maria Lucia Calcagni; M. C. Marzola; A. Garufo; L. Evangelista; R. Maroldi; O. Schillaci; R. Giubbini; M. Bonacina; R. Laudicella; M. Spallino; A. Palucci; M. Cuzzocrea; M. Donner; S. Maurea; F. Ceci; Rossi F. Dei; B. Tranfaglia; A. Sartorello; P. Gandolfo; A. Buschiazzo; A. Scarale; M. Kirienko; N. Merenda; A. G. Nappi; R. Durmo; C. Vellani; V. Ceriani

doi:10.1007/s00259-021-05219-0

Prevalence of interstitial pneumonia suggestive of COVID-19 at 18F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study

D. Albano^*, F. Bertagna, P. Alongi, S. Baldari, A. Baldoncini, M. Bartolomei, F. Boccaletto, M. Boero, E. Borsatti, A. Bruno, L. Burroni, F. Capoccetti, M. Castellani, A. R. Cervino, F. Chierichetti, A. Ciarmiello, A. Corso, A. Cuocolo, Rimini M. L. De, D. DeandreisM. E. Dottorini, F. Esposito, M. Farsad, M. Gasparini, C. M. Grana, M. Gregianin, L. Guerra, F. Loreti, A. Lupi, G. Martino, E. Milan, S. Modoni, S. Morbelli, A. Muni, E. Nicolai, B. Palumbo, S. Papa, A. Papaleo, R. Pellerito, C. Poti, P. Romano, C. Rossetti, P. Rossini, G. Rubini, L. Ruffini, G. Sacchetti, G. Savelli, S. Schiavariello, R. Sciagra, R. Sciuto, E. Seregni, S. Sestini, M. Sicolo, A. Spanu, G. Storto, M. T. Balducci, G. Trifiro, A. Versari, A. Vignati, D. Volterrani, Maria Lucia Calcagni, M. C. Marzola, A. Garufo, L. Evangelista, R. Maroldi, O. Schillaci, R. Giubbini, M. Bonacina, R. Laudicella, M. Spallino, A. Palucci, M. Cuzzocrea, M. Donner, S. Maurea, F. Ceci, Rossi F. Dei, B. Tranfaglia, A. Sartorello, P. Gandolfo, A. Buschiazzo, A. Scarale, M. Kirienko, N. Merenda, A. G. Nappi, R. Durmo, C. Vellani, V. Ceriani

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo

1 Citazioni (Scopus)

Abstract

Purpose: To assess the presence and pattern of incidental interstitial lung alterations suspicious of COVID-19 on fluorine-18-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) ([18F]FDG PET/CT) in asymptomatic oncological patients during the period of active COVID-19 in a country with high prevalence of the virus. Methods: This is a multi-center retrospective observational study involving 59 Italian centers. We retrospectively reviewed the prevalence of interstitial pneumonia detected during the COVID period (between March 16 and 27, 2020) and compared to a pre-COVID period (January–February 2020) and a control time (in 2019). The diagnosis of interstitial pneumonia was done considering lung alterations of CT of PET. Results: Overall, [18F]FDG PET/CT was performed on 4008 patients in the COVID period, 19,267 in the pre-COVID period, and 5513 in the control period. The rate of interstitial pneumonia suspicious for COVID-19 was significantly higher during the COVID period (7.1%) compared with that found in the pre-COVID (5.35%) and control periods (5.15%) (p < 0.001). Instead, no significant difference among pre-COVID and control periods was present. The prevalence of interstitial pneumonia detected at PET/CT was directly associated with geographic virus diffusion, with the higher rate in Northern Italy. Among 284 interstitial pneumonia detected during COVID period, 169 (59%) were FDG-avid (average SUVmax of 4.1). Conclusions: A significant increase of interstitial pneumonia incidentally detected with [18F]FDG PET/CT has been demonstrated during the COVID-19 pandemic. A majority of interstitial pneumonia were FDG-avid. Our results underlined the importance of paying attention to incidental CT findings of pneumonia detected at PET/CT, and these reports might help to recognize early COVID-19 cases guiding the subsequent management.

Lingua originale	Inglese
pagine (da-a)	N/A-N/A
Rivista	European Journal of Nuclear Medicine and Molecular Imaging
Numero di pubblicazione	N/A
DOI	https://doi.org/10.1007/s00259-021-05219-0
Stato di pubblicazione	Pubblicato - 2021

All Science Journal Classification (ASJC) codes

Radiologia, Medicina Nucleare e Diagnostica per Immagini

Keywords

18
Asymptomatic
COVID-19
F-FDG PET/CT
Incidental findings
Interstitial pneumonia
SARS-CoV-2

Accesso al documento

10.1007/s00259-021-05219-0

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Albano, D., Bertagna, F., Alongi, P., Baldari, S., Baldoncini, A., Bartolomei, M., Boccaletto, F., Boero, M., Borsatti, E., Bruno, A., Burroni, L., Capoccetti, F., Castellani, M., Cervino, A. R., Chierichetti, F., Ciarmiello, A., Corso, A., Cuocolo, A., De, R. M. L., ... Ceriani, V. (2021). Prevalence of interstitial pneumonia suggestive of COVID-19 at 18F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study. European Journal of Nuclear Medicine and Molecular Imaging, (N/A), N/A-N/A. https://doi.org/10.1007/s00259-021-05219-0

@article{564a6adefa114c20bc19e74a0a2e4d90,

title = "Prevalence of interstitial pneumonia suggestive of COVID-19 at 18F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study",

abstract = "Purpose: To assess the presence and pattern of incidental interstitial lung alterations suspicious of COVID-19 on fluorine-18-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) ([18F]FDG PET/CT) in asymptomatic oncological patients during the period of active COVID-19 in a country with high prevalence of the virus. Methods: This is a multi-center retrospective observational study involving 59 Italian centers. We retrospectively reviewed the prevalence of interstitial pneumonia detected during the COVID period (between March 16 and 27, 2020) and compared to a pre-COVID period (January–February 2020) and a control time (in 2019). The diagnosis of interstitial pneumonia was done considering lung alterations of CT of PET. Results: Overall, [18F]FDG PET/CT was performed on 4008 patients in the COVID period, 19,267 in the pre-COVID period, and 5513 in the control period. The rate of interstitial pneumonia suspicious for COVID-19 was significantly higher during the COVID period (7.1\%) compared with that found in the pre-COVID (5.35\%) and control periods (5.15\%) (p < 0.001). Instead, no significant difference among pre-COVID and control periods was present. The prevalence of interstitial pneumonia detected at PET/CT was directly associated with geographic virus diffusion, with the higher rate in Northern Italy. Among 284 interstitial pneumonia detected during COVID period, 169 (59\%) were FDG-avid (average SUVmax of 4.1). Conclusions: A significant increase of interstitial pneumonia incidentally detected with [18F]FDG PET/CT has been demonstrated during the COVID-19 pandemic. A majority of interstitial pneumonia were FDG-avid. Our results underlined the importance of paying attention to incidental CT findings of pneumonia detected at PET/CT, and these reports might help to recognize early COVID-19 cases guiding the subsequent management.",

keywords = "18, Asymptomatic, COVID-19, F-FDG PET/CT, Incidental findings, Interstitial pneumonia, SARS-CoV-2, 18, Asymptomatic, COVID-19, F-FDG PET/CT, Incidental findings, Interstitial pneumonia, SARS-CoV-2",

author = "D. Albano and F. Bertagna and P. Alongi and S. Baldari and A. Baldoncini and M. Bartolomei and F. Boccaletto and M. Boero and E. Borsatti and A. Bruno and L. Burroni and F. Capoccetti and M. Castellani and Cervino, \{A. R.\} and F. Chierichetti and A. Ciarmiello and A. Corso and A. Cuocolo and De, \{Rimini M. L.\} and D. Deandreis and Dottorini, \{M. E.\} and F. Esposito and M. Farsad and M. Gasparini and Grana, \{C. M.\} and M. Gregianin and L. Guerra and F. Loreti and A. Lupi and G. Martino and E. Milan and S. Modoni and S. Morbelli and A. Muni and E. Nicolai and B. Palumbo and S. Papa and A. Papaleo and R. Pellerito and C. Poti and P. Romano and C. Rossetti and P. Rossini and G. Rubini and L. Ruffini and G. Sacchetti and G. Savelli and S. Schiavariello and R. Sciagra and R. Sciuto and E. Seregni and S. Sestini and M. Sicolo and A. Spanu and G. Storto and Balducci, \{M. T.\} and G. Trifiro and A. Versari and A. Vignati and D. Volterrani and Calcagni, \{Maria Lucia\} and Marzola, \{M. C.\} and A. Garufo and L. Evangelista and R. Maroldi and O. Schillaci and R. Giubbini and M. Bonacina and R. Laudicella and M. Spallino and A. Palucci and M. Cuzzocrea and M. Donner and S. Maurea and F. Ceci and Dei, \{Rossi F.\} and B. Tranfaglia and A. Sartorello and P. Gandolfo and A. Buschiazzo and A. Scarale and M. Kirienko and N. Merenda and Nappi, \{A. G.\} and R. Durmo and C. Vellani and V. Ceriani",

year = "2021",

doi = "10.1007/s00259-021-05219-0",

language = "English",

pages = "N/A--N/A",

journal = "European Journal of Nuclear Medicine and Molecular Imaging",

issn = "1619-7070",

publisher = "Springer",

number = "N/A",

}

Albano, D, Bertagna, F, Alongi, P, Baldari, S, Baldoncini, A, Bartolomei, M, Boccaletto, F, Boero, M, Borsatti, E, Bruno, A, Burroni, L, Capoccetti, F, Castellani, M, Cervino, AR, Chierichetti, F, Ciarmiello, A, Corso, A, Cuocolo, A, De, RML, Deandreis, D, Dottorini, ME, Esposito, F, Farsad, M, Gasparini, M, Grana, CM, Gregianin, M, Guerra, L, Loreti, F, Lupi, A, Martino, G, Milan, E, Modoni, S, Morbelli, S, Muni, A, Nicolai, E, Palumbo, B, Papa, S, Papaleo, A, Pellerito, R, Poti, C, Romano, P, Rossetti, C, Rossini, P, Rubini, G, Ruffini, L, Sacchetti, G, Savelli, G, Schiavariello, S, Sciagra, R, Sciuto, R, Seregni, E, Sestini, S, Sicolo, M, Spanu, A, Storto, G, Balducci, MT, Trifiro, G, Versari, A, Vignati, A, Volterrani, D, Calcagni, ML, Marzola, MC, Garufo, A, Evangelista, L, Maroldi, R, Schillaci, O, Giubbini, R, Bonacina, M, Laudicella, R, Spallino, M, Palucci, A, Cuzzocrea, M, Donner, M, Maurea, S, Ceci, F, Dei, RF, Tranfaglia, B, Sartorello, A, Gandolfo, P, Buschiazzo, A, Scarale, A, Kirienko, M, Merenda, N, Nappi, AG, Durmo, R, Vellani, C & Ceriani, V 2021, 'Prevalence of interstitial pneumonia suggestive of COVID-19 at 18F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study', European Journal of Nuclear Medicine and Molecular Imaging, n. N/A, pagg. N/A-N/A. https://doi.org/10.1007/s00259-021-05219-0

Prevalence of interstitial pneumonia suggestive of COVID-19 at 18F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study. / Albano, D.; Bertagna, F.; Alongi, P. et al.
In: European Journal of Nuclear Medicine and Molecular Imaging, N. N/A, 2021, pag. N/A-N/A.

Risultato della ricerca: Contributo in rivista › Articolo

TY - JOUR

T1 - Prevalence of interstitial pneumonia suggestive of COVID-19 at 18F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study

AU - Albano, D.

AU - Bertagna, F.

AU - Alongi, P.

AU - Baldari, S.

AU - Baldoncini, A.

AU - Bartolomei, M.

AU - Boccaletto, F.

AU - Boero, M.

AU - Borsatti, E.

AU - Bruno, A.

AU - Burroni, L.

AU - Capoccetti, F.

AU - Castellani, M.

AU - Cervino, A. R.

AU - Chierichetti, F.

AU - Ciarmiello, A.

AU - Corso, A.

AU - Cuocolo, A.

AU - De, Rimini M. L.

AU - Deandreis, D.

AU - Dottorini, M. E.

AU - Esposito, F.

AU - Farsad, M.

AU - Gasparini, M.

AU - Grana, C. M.

AU - Gregianin, M.

AU - Guerra, L.

AU - Loreti, F.

AU - Lupi, A.

AU - Martino, G.

AU - Milan, E.

AU - Modoni, S.

AU - Morbelli, S.

AU - Muni, A.

AU - Nicolai, E.

AU - Palumbo, B.

AU - Papa, S.

AU - Papaleo, A.

AU - Pellerito, R.

AU - Poti, C.

AU - Romano, P.

AU - Rossetti, C.

AU - Rossini, P.

AU - Rubini, G.

AU - Ruffini, L.

AU - Sacchetti, G.

AU - Savelli, G.

AU - Schiavariello, S.

AU - Sciagra, R.

AU - Sciuto, R.

AU - Seregni, E.

AU - Sestini, S.

AU - Sicolo, M.

AU - Spanu, A.

AU - Storto, G.

AU - Balducci, M. T.

AU - Trifiro, G.

AU - Versari, A.

AU - Vignati, A.

AU - Volterrani, D.

AU - Calcagni, Maria Lucia

AU - Marzola, M. C.

AU - Garufo, A.

AU - Evangelista, L.

AU - Maroldi, R.

AU - Schillaci, O.

AU - Giubbini, R.

AU - Bonacina, M.

AU - Laudicella, R.

AU - Spallino, M.

AU - Palucci, A.

AU - Cuzzocrea, M.

AU - Donner, M.

AU - Maurea, S.

AU - Ceci, F.

AU - Dei, Rossi F.

AU - Tranfaglia, B.

AU - Sartorello, A.

AU - Gandolfo, P.

AU - Buschiazzo, A.

AU - Scarale, A.

AU - Kirienko, M.

AU - Merenda, N.

AU - Nappi, A. G.

AU - Durmo, R.

AU - Vellani, C.

AU - Ceriani, V.

PY - 2021

Y1 - 2021

N2 - Purpose: To assess the presence and pattern of incidental interstitial lung alterations suspicious of COVID-19 on fluorine-18-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) ([18F]FDG PET/CT) in asymptomatic oncological patients during the period of active COVID-19 in a country with high prevalence of the virus. Methods: This is a multi-center retrospective observational study involving 59 Italian centers. We retrospectively reviewed the prevalence of interstitial pneumonia detected during the COVID period (between March 16 and 27, 2020) and compared to a pre-COVID period (January–February 2020) and a control time (in 2019). The diagnosis of interstitial pneumonia was done considering lung alterations of CT of PET. Results: Overall, [18F]FDG PET/CT was performed on 4008 patients in the COVID period, 19,267 in the pre-COVID period, and 5513 in the control period. The rate of interstitial pneumonia suspicious for COVID-19 was significantly higher during the COVID period (7.1%) compared with that found in the pre-COVID (5.35%) and control periods (5.15%) (p < 0.001). Instead, no significant difference among pre-COVID and control periods was present. The prevalence of interstitial pneumonia detected at PET/CT was directly associated with geographic virus diffusion, with the higher rate in Northern Italy. Among 284 interstitial pneumonia detected during COVID period, 169 (59%) were FDG-avid (average SUVmax of 4.1). Conclusions: A significant increase of interstitial pneumonia incidentally detected with [18F]FDG PET/CT has been demonstrated during the COVID-19 pandemic. A majority of interstitial pneumonia were FDG-avid. Our results underlined the importance of paying attention to incidental CT findings of pneumonia detected at PET/CT, and these reports might help to recognize early COVID-19 cases guiding the subsequent management.

AB - Purpose: To assess the presence and pattern of incidental interstitial lung alterations suspicious of COVID-19 on fluorine-18-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) ([18F]FDG PET/CT) in asymptomatic oncological patients during the period of active COVID-19 in a country with high prevalence of the virus. Methods: This is a multi-center retrospective observational study involving 59 Italian centers. We retrospectively reviewed the prevalence of interstitial pneumonia detected during the COVID period (between March 16 and 27, 2020) and compared to a pre-COVID period (January–February 2020) and a control time (in 2019). The diagnosis of interstitial pneumonia was done considering lung alterations of CT of PET. Results: Overall, [18F]FDG PET/CT was performed on 4008 patients in the COVID period, 19,267 in the pre-COVID period, and 5513 in the control period. The rate of interstitial pneumonia suspicious for COVID-19 was significantly higher during the COVID period (7.1%) compared with that found in the pre-COVID (5.35%) and control periods (5.15%) (p < 0.001). Instead, no significant difference among pre-COVID and control periods was present. The prevalence of interstitial pneumonia detected at PET/CT was directly associated with geographic virus diffusion, with the higher rate in Northern Italy. Among 284 interstitial pneumonia detected during COVID period, 169 (59%) were FDG-avid (average SUVmax of 4.1). Conclusions: A significant increase of interstitial pneumonia incidentally detected with [18F]FDG PET/CT has been demonstrated during the COVID-19 pandemic. A majority of interstitial pneumonia were FDG-avid. Our results underlined the importance of paying attention to incidental CT findings of pneumonia detected at PET/CT, and these reports might help to recognize early COVID-19 cases guiding the subsequent management.

KW - 18

KW - Asymptomatic

KW - COVID-19

KW - F-FDG PET/CT

KW - Incidental findings

KW - Interstitial pneumonia

KW - SARS-CoV-2

KW - 18

KW - Asymptomatic

KW - COVID-19

KW - F-FDG PET/CT

KW - Incidental findings

KW - Interstitial pneumonia

KW - SARS-CoV-2

UR - https://publicatt.unicatt.it/handle/10807/177058

UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85100869803&origin=inward

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85100869803&origin=inward

U2 - 10.1007/s00259-021-05219-0

DO - 10.1007/s00259-021-05219-0

M3 - Article

SN - 1619-7070

SP - N/A-N/A

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

IS - N/A

ER -

Albano D, Bertagna F, Alongi P, Baldari S, Baldoncini A, Bartolomei M et al. Prevalence of interstitial pneumonia suggestive of COVID-19 at 18F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study. European Journal of Nuclear Medicine and Molecular Imaging. 2021;(N/A):N/A-N/A. doi: 10.1007/s00259-021-05219-0