Prevalence of interstitial pneumonia suggestive of COVID-19 at 18F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study

Domenico Albano; Francesco Bertagna; Pierpaolo Alongi; Sergio Baldari; Alfonso Baldoncini; Mirco Bartolomei; Franco Boccaletto; Michele Boero; Eugenio Borsatti; Andrea Bruno; Luca Burroni; Francesca Capoccetti; Massimo Castellani; Anna Rita Cervino; Franca Chierichetti; Andrea Ciarmiello; Angelo Corso; Alberto Cuocolo; Maria Luisa De Rimini; Desiree’ Deandreis; Massimo Eugenio Dottorini; Filomena Esposito; Francesca Esposito; Mohsen Farsad; Massimo Gasparini; Chiara Maria Grana; Michele Gregianin; Luca Guerra; Fabio Loreti; Andrea Lupi; Alessandro Lupi; Gianluigi Martino; Elisa Milan; Sergio Modoni; Silvia Morbelli; Alfredo Muni; Emanuele Nicolai; Barbara Palumbo; Sergio Papa; Alberto Papaleo; Riccardo Pellerito; Carlo Poti; Pasquale Romano; Claudio Rossetti; Chiara Rossetti; Pierluigi Rossini; Paolo Maria Rossini; Giuseppe Rubini; Livia Ruffini; Gianmauro Sacchetti; Giordano Savelli; Saverio Schiavariello; Roberto Sciagrà; Rosa Sciuto; Ettore Seregni; Stelvio Sestini; Michele Sicolo; Angela Spanu; Giovanni Storto; Massimo Tosti Balducci; Giuseppe Trifirò; Annibale Versari; Alberto Vignati; Duccio Volterrani; Maria Lucia Calcagni; Maria Cristina Marzola; Antonio Garufo; Laura Evangelista; Roberto Maroldi; Orazio Schillaci; Raffaele Giubbini; M. Bonacina; R. Laudicella; M. Spallino; A. Palucci; M. Cuzzocrea; M. Donner; S. Maurea; F. Ceci; F. Dei Rossi; B. Tranfaglia; A. Sartorello; P. Gandolfo; A. Buschiazzo; A. Scarale; M. Kirienko; N. Merenda; A. G. Nappi; R. Durmo; C. Vellani; V. Ceriani

doi:10.1007/s00259-021-05219-0

Prevalence of interstitial pneumonia suggestive of COVID-19 at 18F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study

Domenico Albano, Francesco Bertagna, Pierpaolo Alongi, Sergio Baldari, Alfonso Baldoncini, Mirco Bartolomei, Franco Boccaletto, Michele Boero, Eugenio Borsatti, Andrea Bruno, Luca Burroni, Francesca Capoccetti, Massimo Castellani, Anna Rita Cervino, Franca Chierichetti, Andrea Ciarmiello, Angelo Corso, Alberto Cuocolo, Maria Luisa De Rimini, Desiree’ DeandreisMassimo Eugenio Dottorini, Filomena Esposito, Francesca Esposito, Mohsen Farsad, Massimo Gasparini, Chiara Maria Grana, Michele Gregianin, Luca Guerra, Fabio Loreti, Andrea Lupi, Alessandro Lupi, Gianluigi Martino, Elisa Milan, Sergio Modoni, Silvia Morbelli, Alfredo Muni, Emanuele Nicolai, Barbara Palumbo, Sergio Papa, Alberto Papaleo, Riccardo Pellerito, Carlo Poti, Pasquale Romano, Claudio Rossetti, Chiara Rossetti, Pierluigi Rossini, Paolo Maria Rossini, Giuseppe Rubini, Livia Ruffini, Gianmauro Sacchetti, Giordano Savelli, Saverio Schiavariello, Roberto Sciagrà, Rosa Sciuto, Ettore Seregni, Stelvio Sestini, Michele Sicolo, Angela Spanu, Giovanni Storto, Massimo Tosti Balducci, Giuseppe Trifirò, Annibale Versari, Alberto Vignati, Duccio Volterrani, Maria Lucia Calcagni, Maria Cristina Marzola, Antonio Garufo, Laura Evangelista, Roberto Maroldi, Orazio Schillaci, Raffaele Giubbini, M. Bonacina, R. Laudicella, M. Spallino, A. Palucci, M. Cuzzocrea, M. Donner, S. Maurea, F. Ceci, F. Dei Rossi, B. Tranfaglia, A. Sartorello, P. Gandolfo, A. Buschiazzo, A. Scarale, M. Kirienko, N. Merenda, A. G. Nappi, R. Durmo, C. Vellani, V. Ceriani

Risultato della ricerca: Contributo in rivista › Articolo in rivista

1 Citazioni (Scopus)

Abstract

Purpose: To assess the presence and pattern of incidental interstitial lung alterations suspicious of COVID-19 on fluorine-18-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) ([18F]FDG PET/CT) in asymptomatic oncological patients during the period of active COVID-19 in a country with high prevalence of the virus. Methods: This is a multi-center retrospective observational study involving 59 Italian centers. We retrospectively reviewed the prevalence of interstitial pneumonia detected during the COVID period (between March 16 and 27, 2020) and compared to a pre-COVID period (January–February 2020) and a control time (in 2019). The diagnosis of interstitial pneumonia was done considering lung alterations of CT of PET. Results: Overall, [18F]FDG PET/CT was performed on 4008 patients in the COVID period, 19,267 in the pre-COVID period, and 5513 in the control period. The rate of interstitial pneumonia suspicious for COVID-19 was significantly higher during the COVID period (7.1%) compared with that found in the pre-COVID (5.35%) and control periods (5.15%) (p < 0.001). Instead, no significant difference among pre-COVID and control periods was present. The prevalence of interstitial pneumonia detected at PET/CT was directly associated with geographic virus diffusion, with the higher rate in Northern Italy. Among 284 interstitial pneumonia detected during COVID period, 169 (59%) were FDG-avid (average SUVmax of 4.1). Conclusions: A significant increase of interstitial pneumonia incidentally detected with [18F]FDG PET/CT has been demonstrated during the COVID-19 pandemic. A majority of interstitial pneumonia were FDG-avid. Our results underlined the importance of paying attention to incidental CT findings of pneumonia detected at PET/CT, and these reports might help to recognize early COVID-19 cases guiding the subsequent management.

Lingua originale	English
pagine (da-a)	N/A-N/A
Rivista	European Journal of Nuclear Medicine and Molecular Imaging
DOI	https://doi.org/10.1007/s00259-021-05219-0
Stato di pubblicazione	Pubblicato - 2021

Keywords

18
Asymptomatic
COVID-19
F-FDG PET/CT
Incidental findings
Interstitial pneumonia
SARS-CoV-2

Accesso al documento

10.1007/s00259-021-05219-0

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Albano, D., Bertagna, F., Alongi, P., Baldari, S., Baldoncini, A., Bartolomei, M., Boccaletto, F., Boero, M., Borsatti, E., Bruno, A., Burroni, L., Capoccetti, F., Castellani, M., Cervino, A. R., Chierichetti, F., Ciarmiello, A., Corso, A., Cuocolo, A., De Rimini, M. L., ... Ceriani, V. (2021). Prevalence of interstitial pneumonia suggestive of COVID-19 at 18F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study. European Journal of Nuclear Medicine and Molecular Imaging, N/A-N/A. https://doi.org/10.1007/s00259-021-05219-0

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title = "Prevalence of interstitial pneumonia suggestive of COVID-19 at 18F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study",

abstract = "Purpose: To assess the presence and pattern of incidental interstitial lung alterations suspicious of COVID-19 on fluorine-18-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) ([18F]FDG PET/CT) in asymptomatic oncological patients during the period of active COVID-19 in a country with high prevalence of the virus. Methods: This is a multi-center retrospective observational study involving 59 Italian centers. We retrospectively reviewed the prevalence of interstitial pneumonia detected during the COVID period (between March 16 and 27, 2020) and compared to a pre-COVID period (January–February 2020) and a control time (in 2019). The diagnosis of interstitial pneumonia was done considering lung alterations of CT of PET. Results: Overall, [18F]FDG PET/CT was performed on 4008 patients in the COVID period, 19,267 in the pre-COVID period, and 5513 in the control period. The rate of interstitial pneumonia suspicious for COVID-19 was significantly higher during the COVID period (7.1%) compared with that found in the pre-COVID (5.35%) and control periods (5.15%) (p < 0.001). Instead, no significant difference among pre-COVID and control periods was present. The prevalence of interstitial pneumonia detected at PET/CT was directly associated with geographic virus diffusion, with the higher rate in Northern Italy. Among 284 interstitial pneumonia detected during COVID period, 169 (59%) were FDG-avid (average SUVmax of 4.1). Conclusions: A significant increase of interstitial pneumonia incidentally detected with [18F]FDG PET/CT has been demonstrated during the COVID-19 pandemic. A majority of interstitial pneumonia were FDG-avid. Our results underlined the importance of paying attention to incidental CT findings of pneumonia detected at PET/CT, and these reports might help to recognize early COVID-19 cases guiding the subsequent management.",

keywords = "18, Asymptomatic, COVID-19, F-FDG PET/CT, Incidental findings, Interstitial pneumonia, SARS-CoV-2, 18, Asymptomatic, COVID-19, F-FDG PET/CT, Incidental findings, Interstitial pneumonia, SARS-CoV-2",

author = "Domenico Albano and Francesco Bertagna and Pierpaolo Alongi and Sergio Baldari and Alfonso Baldoncini and Mirco Bartolomei and Franco Boccaletto and Michele Boero and Eugenio Borsatti and Andrea Bruno and Luca Burroni and Francesca Capoccetti and Massimo Castellani and Cervino, {Anna Rita} and Franca Chierichetti and Andrea Ciarmiello and Angelo Corso and Alberto Cuocolo and {De Rimini}, {Maria Luisa} and Desiree{\textquoteright} Deandreis and Dottorini, {Massimo Eugenio} and Filomena Esposito and Francesca Esposito and Mohsen Farsad and Massimo Gasparini and Grana, {Chiara Maria} and Michele Gregianin and Luca Guerra and Fabio Loreti and Andrea Lupi and Alessandro Lupi and Gianluigi Martino and Elisa Milan and Sergio Modoni and Silvia Morbelli and Alfredo Muni and Emanuele Nicolai and Barbara Palumbo and Sergio Papa and Alberto Papaleo and Riccardo Pellerito and Carlo Poti and Pasquale Romano and Claudio Rossetti and Chiara Rossetti and Pierluigi Rossini and Rossini, {Paolo Maria} and Giuseppe Rubini and Livia Ruffini and Gianmauro Sacchetti and Giordano Savelli and Saverio Schiavariello and Roberto Sciagr{\`a} and Rosa Sciuto and Ettore Seregni and Stelvio Sestini and Michele Sicolo and Angela Spanu and Giovanni Storto and Balducci, {Massimo Tosti} and Giuseppe Trifir{\`o} and Annibale Versari and Alberto Vignati and Duccio Volterrani and Calcagni, {Maria Lucia} and Marzola, {Maria Cristina} and Antonio Garufo and Laura Evangelista and Roberto Maroldi and Orazio Schillaci and Raffaele Giubbini and M. Bonacina and R. Laudicella and M. Spallino and A. Palucci and M. Cuzzocrea and M. Donner and S. Maurea and F. Ceci and {Dei Rossi}, F. and B. Tranfaglia and A. Sartorello and P. Gandolfo and A. Buschiazzo and A. Scarale and M. Kirienko and N. Merenda and Nappi, {A. G.} and R. Durmo and C. Vellani and V. Ceriani",

year = "2021",

doi = "10.1007/s00259-021-05219-0",

language = "English",

pages = "N/A--N/A",

journal = "European Journal of Nuclear Medicine and Molecular Imaging",

issn = "1619-7070",

publisher = "Springer Verlag Germany:Tiergartenstrasse 17, D 69121 Heidelberg Germany:011 49 6221 3450, EMAIL: g.braun@springer.de, INTERNET: http://www.springer.de, Fax: 011 49 6221 345229",

}

Albano, D, Bertagna, F, Alongi, P, Baldari, S, Baldoncini, A, Bartolomei, M, Boccaletto, F, Boero, M, Borsatti, E, Bruno, A, Burroni, L, Capoccetti, F, Castellani, M, Cervino, AR, Chierichetti, F, Ciarmiello, A, Corso, A, Cuocolo, A, De Rimini, ML, Deandreis, D, Dottorini, ME, Esposito, F, Esposito, F, Farsad, M, Gasparini, M, Grana, CM, Gregianin, M, Guerra, L, Loreti, F, Lupi, A, Lupi, A, Martino, G, Milan, E, Modoni, S, Morbelli, S, Muni, A, Nicolai, E, Palumbo, B, Papa, S, Papaleo, A, Pellerito, R, Poti, C, Romano, P, Rossetti, C, Rossetti, C, Rossini, P, Rossini, PM, Rubini, G, Ruffini, L, Sacchetti, G, Savelli, G, Schiavariello, S, Sciagrà, R, Sciuto, R, Seregni, E, Sestini, S, Sicolo, M, Spanu, A, Storto, G, Balducci, MT, Trifirò, G, Versari, A, Vignati, A, Volterrani, D, Calcagni, ML, Marzola, MC, Garufo, A, Evangelista, L, Maroldi, R, Schillaci, O, Giubbini, R, Bonacina, M, Laudicella, R, Spallino, M, Palucci, A, Cuzzocrea, M, Donner, M, Maurea, S, Ceci, F, Dei Rossi, F, Tranfaglia, B, Sartorello, A, Gandolfo, P, Buschiazzo, A, Scarale, A, Kirienko, M, Merenda, N, Nappi, AG, Durmo, R, Vellani, C & Ceriani, V 2021, 'Prevalence of interstitial pneumonia suggestive of COVID-19 at 18F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study', European Journal of Nuclear Medicine and Molecular Imaging, pagg. N/A-N/A. https://doi.org/10.1007/s00259-021-05219-0

Prevalence of interstitial pneumonia suggestive of COVID-19 at 18F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study. / Albano, Domenico; Bertagna, Francesco; Alongi, Pierpaolo et al.

In: European Journal of Nuclear Medicine and Molecular Imaging, 2021, pag. N/A-N/A.

Risultato della ricerca: Contributo in rivista › Articolo in rivista

TY - JOUR

T1 - Prevalence of interstitial pneumonia suggestive of COVID-19 at 18F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study

AU - Albano, Domenico

AU - Bertagna, Francesco

AU - Alongi, Pierpaolo

AU - Baldari, Sergio

AU - Baldoncini, Alfonso

AU - Bartolomei, Mirco

AU - Boccaletto, Franco

AU - Boero, Michele

AU - Borsatti, Eugenio

AU - Bruno, Andrea

AU - Burroni, Luca

AU - Capoccetti, Francesca

AU - Castellani, Massimo

AU - Cervino, Anna Rita

AU - Chierichetti, Franca

AU - Ciarmiello, Andrea

AU - Corso, Angelo

AU - Cuocolo, Alberto

AU - De Rimini, Maria Luisa

AU - Deandreis, Desiree’

AU - Dottorini, Massimo Eugenio

AU - Esposito, Filomena

AU - Esposito, Francesca

AU - Farsad, Mohsen

AU - Gasparini, Massimo

AU - Grana, Chiara Maria

AU - Gregianin, Michele

AU - Guerra, Luca

AU - Loreti, Fabio

AU - Lupi, Andrea

AU - Lupi, Alessandro

AU - Martino, Gianluigi

AU - Milan, Elisa

AU - Modoni, Sergio

AU - Morbelli, Silvia

AU - Muni, Alfredo

AU - Nicolai, Emanuele

AU - Palumbo, Barbara

AU - Papa, Sergio

AU - Papaleo, Alberto

AU - Pellerito, Riccardo

AU - Poti, Carlo

AU - Romano, Pasquale

AU - Rossetti, Claudio

AU - Rossetti, Chiara

AU - Rossini, Pierluigi

AU - Rossini, Paolo Maria

AU - Rubini, Giuseppe

AU - Ruffini, Livia

AU - Sacchetti, Gianmauro

AU - Savelli, Giordano

AU - Schiavariello, Saverio

AU - Sciagrà, Roberto

AU - Sciuto, Rosa

AU - Seregni, Ettore

AU - Sestini, Stelvio

AU - Sicolo, Michele

AU - Spanu, Angela

AU - Storto, Giovanni

AU - Balducci, Massimo Tosti

AU - Trifirò, Giuseppe

AU - Versari, Annibale

AU - Vignati, Alberto

AU - Volterrani, Duccio

AU - Calcagni, Maria Lucia

AU - Marzola, Maria Cristina

AU - Garufo, Antonio

AU - Evangelista, Laura

AU - Maroldi, Roberto

AU - Schillaci, Orazio

AU - Giubbini, Raffaele

AU - Bonacina, M.

AU - Laudicella, R.

AU - Spallino, M.

AU - Palucci, A.

AU - Cuzzocrea, M.

AU - Donner, M.

AU - Maurea, S.

AU - Ceci, F.

AU - Dei Rossi, F.

AU - Tranfaglia, B.

AU - Sartorello, A.

AU - Gandolfo, P.

AU - Buschiazzo, A.

AU - Scarale, A.

AU - Kirienko, M.

AU - Merenda, N.

AU - Nappi, A. G.

AU - Durmo, R.

AU - Vellani, C.

AU - Ceriani, V.

PY - 2021

Y1 - 2021

N2 - Purpose: To assess the presence and pattern of incidental interstitial lung alterations suspicious of COVID-19 on fluorine-18-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) ([18F]FDG PET/CT) in asymptomatic oncological patients during the period of active COVID-19 in a country with high prevalence of the virus. Methods: This is a multi-center retrospective observational study involving 59 Italian centers. We retrospectively reviewed the prevalence of interstitial pneumonia detected during the COVID period (between March 16 and 27, 2020) and compared to a pre-COVID period (January–February 2020) and a control time (in 2019). The diagnosis of interstitial pneumonia was done considering lung alterations of CT of PET. Results: Overall, [18F]FDG PET/CT was performed on 4008 patients in the COVID period, 19,267 in the pre-COVID period, and 5513 in the control period. The rate of interstitial pneumonia suspicious for COVID-19 was significantly higher during the COVID period (7.1%) compared with that found in the pre-COVID (5.35%) and control periods (5.15%) (p < 0.001). Instead, no significant difference among pre-COVID and control periods was present. The prevalence of interstitial pneumonia detected at PET/CT was directly associated with geographic virus diffusion, with the higher rate in Northern Italy. Among 284 interstitial pneumonia detected during COVID period, 169 (59%) were FDG-avid (average SUVmax of 4.1). Conclusions: A significant increase of interstitial pneumonia incidentally detected with [18F]FDG PET/CT has been demonstrated during the COVID-19 pandemic. A majority of interstitial pneumonia were FDG-avid. Our results underlined the importance of paying attention to incidental CT findings of pneumonia detected at PET/CT, and these reports might help to recognize early COVID-19 cases guiding the subsequent management.

AB - Purpose: To assess the presence and pattern of incidental interstitial lung alterations suspicious of COVID-19 on fluorine-18-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) ([18F]FDG PET/CT) in asymptomatic oncological patients during the period of active COVID-19 in a country with high prevalence of the virus. Methods: This is a multi-center retrospective observational study involving 59 Italian centers. We retrospectively reviewed the prevalence of interstitial pneumonia detected during the COVID period (between March 16 and 27, 2020) and compared to a pre-COVID period (January–February 2020) and a control time (in 2019). The diagnosis of interstitial pneumonia was done considering lung alterations of CT of PET. Results: Overall, [18F]FDG PET/CT was performed on 4008 patients in the COVID period, 19,267 in the pre-COVID period, and 5513 in the control period. The rate of interstitial pneumonia suspicious for COVID-19 was significantly higher during the COVID period (7.1%) compared with that found in the pre-COVID (5.35%) and control periods (5.15%) (p < 0.001). Instead, no significant difference among pre-COVID and control periods was present. The prevalence of interstitial pneumonia detected at PET/CT was directly associated with geographic virus diffusion, with the higher rate in Northern Italy. Among 284 interstitial pneumonia detected during COVID period, 169 (59%) were FDG-avid (average SUVmax of 4.1). Conclusions: A significant increase of interstitial pneumonia incidentally detected with [18F]FDG PET/CT has been demonstrated during the COVID-19 pandemic. A majority of interstitial pneumonia were FDG-avid. Our results underlined the importance of paying attention to incidental CT findings of pneumonia detected at PET/CT, and these reports might help to recognize early COVID-19 cases guiding the subsequent management.

KW - 18

KW - Asymptomatic

KW - COVID-19

KW - F-FDG PET/CT

KW - Incidental findings

KW - Interstitial pneumonia

KW - SARS-CoV-2

KW - 18

KW - Asymptomatic

KW - COVID-19

KW - F-FDG PET/CT

KW - Incidental findings

KW - Interstitial pneumonia

KW - SARS-CoV-2

UR - http://hdl.handle.net/10807/177058

U2 - 10.1007/s00259-021-05219-0

DO - 10.1007/s00259-021-05219-0

M3 - Article

SN - 1619-7070

SP - N/A-N/A

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

ER -

Albano D, Bertagna F, Alongi P, Baldari S, Baldoncini A, Bartolomei M et al. Prevalence of interstitial pneumonia suggestive of COVID-19 at 18F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study. European Journal of Nuclear Medicine and Molecular Imaging. 2021;N/A-N/A. doi: 10.1007/s00259-021-05219-0