Prevalence of HPV Infection in Racial-Ethnic Subgroups of Head and Neck Cancer Patients

Francesco Bussu, Camille Ragin, Jeffrey C. Liu, Gieira Jones, Olubunmi Shoyele, Bukola Sowunmi, Rachel Kennett, Denise Gibbs, Elizabeth Blackman, Michael Esan, Margaret S. Brandwein, Karthik Devarajan, Rebecca Chernock, Chih-Yen Chien, Marc A. Cohen, Samir El-Mofty, Mikio Suzuki, Gypsyamber D'Souza, Pauline Funchain, Charis EngSusanne M. Gollin, Angela Hong, Yuh-S. Jung, Maximilian Krüger, James Lewis, Patrizia Morbini, Santo Landolfo, Massimo Rittà, Jos Straetmans, Krisztina Szarka, Ruth Tachezy, Francis P. Worden, Deborah Nelson, Samuel Gathere, Emanuela Taioli

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

14 Citazioni (Scopus)

Abstract

The landscape of HPV infection in racial/ethnic subgroups of head and neck cancer (HNC) patients has not been evaluated carefully. In this study, a meta-analysis examined the prevalence of HPV in HNC patients of African ancestry. Additionally, a pooled analysis of subject-level data was also performed to investigate HPV prevalence and patterns of p16 (CDNK2A) expression amongst different racial groups. Eighteen publications (N = 798 Black HNC patients) were examined in the meta-analysis, and the pooled analysis included 29 datasets comprised of 3,129 HNC patients of diverse racial/ethnic background. The meta-analysis revealed that the prevalence of HPV16 was higher among Blacks with oropharyngeal cancer than Blacks with non-oropharyngeal cancer. However, there was great heterogeneity observed among studies (Q test P<0.0001). In the pooled analysis, after adjusting for each study, year of diagnosis, age, gender and smoking status, the prevalence of HPV16/18 in oropharyngeal cancer patients was highest in Whites (61.1%), followed by 58.0% in Blacks and 25.2% in Asians (P<0.0001). There was no statistically significant difference in HPV16/18 prevalence in non-oropharyngeal cancer by race (P=0.682). With regard to the pattern of HPV16/18 status and p16 expression, White patients had the highest proportion of HPV16/18+/p16+ oropharyngeal cancer (52.3%), while Asians and Blacks had significantly lower proportions (23.0% and 22.6%, respectively) [P <0.0001]. Our findings suggest that the pattern of HPV16/18 status and p16 expression in oropharyngeal cancer appears to differ by race and this may contribute to survival disparities.
Lingua originaleEnglish
pagine (da-a)218-229
Numero di pagine12
RivistaCarcinogenesis
Volume38
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • HPV
  • oropharyngeal cancer

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