Prevalence and predictors of bowel dysfunction in a large multiple sclerosis outpatient population: an Italian multicenter study

Bisecco Alvino, Fornasiero Arianna, Assunta Bianco, Cortese Antonio, D’Amico Emanuele, Mataluni Giorgia, Sinisi Leonardo, Spitaleri Daniele, Docimo Renato, Maria Chiara Buscarinu, Massimiliano Mirabella, Sebastiano Giuseppe Crisafulli, Zanghì Aurora, Carolina Gabri Nicoletti, Salvetti Marco, Baione Viola, Patti Francesco, Alessandra Girolama Marfia, Sibilia Grazia, Scarano ValentinaOrlando Davide, Stabile Giovanni, Tedeschi Gioacchino, Antonio Gallo

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review


Introduction: Bowel dysfunction (BD) is reported as a common and disabling symptom in multiple sclerosis (MS) patients. To date, no studies have explored the prevalence of these symptoms in a large multicenter outpatient setting. The aims of the present study are to assess: (i) the prevalence of BD in a large multicenter Italian MS population, and (ii) the correlation between clinico-demographic variables and the severity of BD. Methods: Each of the nine participating center screened MS patients prospectively: 1100 subjects were enrolled. All patients underwent the Expanded Disability Status Scale (EDSS) and completed the Neurogenic Bowel Dysfunction score (NBDs). Multivariable linear and logistic regression models were used to assess the association between NBDs and several clinico-demographic variables. Results: Fourteen percent of MS patients showed a moderate/severe BD (NBDs > 10); this percentage increased in patients with high disability, ranging from 26 to 32%. Moderate/severe BD was more frequent in MS patients with: progressive phenotypes, higher disability, older age, and longer disease duration. NBDs severity was predicted by female sex, ambulation impairment and bladder symptoms. Conclusion: This study confirms the relatively high prevalence of moderate/severe BD in a large, multicenter, unselected, outpatient MS population. BD appears to be mainly associated to female sex and MS-related disability.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaJournal of Neurology
Stato di pubblicazionePubblicato - 2021


  • Bowel
  • Gut dysfunction
  • Multicenter study
  • Multiple sclerosis
  • Symptoms


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