Pretreatment neuropsychological deficits in children with brain tumors

L. Iuvone, Laura Iuvone, Laura Peruzzi, Cesare Colosimo, Gianpiero Tamburrini, Massimo Caldarelli, Concezio Di Rocco, Domenica Immacolata Battaglia, Francesco Guzzetta, S. Misciagna, Angela Di Giannatale, Antonio Ruggiero, Riccardo Riccardi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

30 Citazioni (Scopus)


Treatment of childhood brain cancer has been associated with long-term cognitive morbidity in children. In the present study, the cognitive status of children with brain tumors was examined prior to any treatment to single out the role of tumor and tumor-related factors in cognitive deficits. Eighty-three children with newly diagnosed brain tumors (mean age, 8.6 years; range, 7 months to 16.6 years; median, 9.4 years) completed an extensive battery of age-related tests to assess cognitive function before any therapeutic intervention. Magnetic resonance imaging (MRI) was used to determine tumor site and volume and tumor-related factors. Performance under test was compared with symptom duration, neurological status, epilepsy, and MRI. Cognitive difficulties are detected at diagnosis in as many as 50% of patients for some cognitive domains; 6% of patients present with true-diagnosed mental retardation. The location of the tumor is the principal determinant of cognitive deficits, with major impairment in children with cortical tumors. Symptom duration and the presence of epilepsy are significantly associated with neuropsychological disabilities, while neuroradiological tumor-related variables do not correlate clearly with neurocognitive performance. The knowledge of the pre-existing cognitive deficits is critical to evaluate the results of treatment, providing a baseline for assessing the true impact of therapy in determining cognitive decline. In addition, the study suggests that some clinical variables require careful monitoring, because they could be specifically implicated in the neuropsychological outcome; the efforts to reduce the impact of these factors could ameliorate long-term prognosis.
Lingua originaleEnglish
pagine (da-a)517-524
Numero di pagine8
Stato di pubblicazionePubblicato - 2011


  • brain tumors
  • children
  • neurocognitive tests
  • neuropsychological deficit


Entra nei temi di ricerca di 'Pretreatment neuropsychological deficits in children with brain tumors'. Insieme formano una fingerprint unica.

Cita questo