TY - JOUR
T1 - Preterm small for gestational age infants are not at higher risk for parenteral nutrition-associated cholestasis.
AU - Costa, Simonetta
AU - Maggio, Luca
AU - Sindico, Paola
AU - Cota, Francesco
AU - De Carolis, Maria Pia
AU - Romagnoli, Costantino
PY - 2010
Y1 - 2010
N2 - OBJECTIVE: To assess if being small for gestational age impacts parenteral
nutrition-associated cholestasis (PNAC) development.
STUDY DESIGN: We reviewed all the very low-birth weight infants exposed to
parenteral nutrition for >14 days from 1996 to 2006, comparing auxological and
clinical data, as well as nutritional history, during the first 4 weeks of life
of infants with cholestasis and control subjects.
RESULTS: Of 445 very low-birth weight infants, 55 had development of PNAC.
Infants with cholestasis had lower birth weight and gestational age but similar
birth weight z-score compared with infants without cholestasis, and they received
a lower amount of enteral feeds (25.8 +/- 20.7 vs 67.9 +/- 33.0 mL/kg, P < .001),
a greater amount of intravenous glucose (10.6 +/- 1.3 vs 7.5 +/- 2.5 g/kg, P <
.0001), lipids (1.8 +/- 0.4 vs 1.3 +/- 0.5, P < .0001) and proteins (2.7 +/- 0.5
vs 1.9 +/- 0.7, P < .0001), and needed a higher number of days of fasting (13.2
+/- 6.7 vs 6.5 +/- 4.8, P < .001). Enteral intake between 0 and 21 days of life
(OR 0.66; 95% CI 0.53, 0.81, P < .0001) and oxygen therapy (OR 1.05; 95% CI 1.01,
1.09; P = .030) were identified as the best independent predictors of PNAC.
CONCLUSIONS: Enteral feeding remains the main factor for the prevention of PNAC,
whereas small for gestational age infants do not have a higher risk of PNAC.
AB - OBJECTIVE: To assess if being small for gestational age impacts parenteral
nutrition-associated cholestasis (PNAC) development.
STUDY DESIGN: We reviewed all the very low-birth weight infants exposed to
parenteral nutrition for >14 days from 1996 to 2006, comparing auxological and
clinical data, as well as nutritional history, during the first 4 weeks of life
of infants with cholestasis and control subjects.
RESULTS: Of 445 very low-birth weight infants, 55 had development of PNAC.
Infants with cholestasis had lower birth weight and gestational age but similar
birth weight z-score compared with infants without cholestasis, and they received
a lower amount of enteral feeds (25.8 +/- 20.7 vs 67.9 +/- 33.0 mL/kg, P < .001),
a greater amount of intravenous glucose (10.6 +/- 1.3 vs 7.5 +/- 2.5 g/kg, P <
.0001), lipids (1.8 +/- 0.4 vs 1.3 +/- 0.5, P < .0001) and proteins (2.7 +/- 0.5
vs 1.9 +/- 0.7, P < .0001), and needed a higher number of days of fasting (13.2
+/- 6.7 vs 6.5 +/- 4.8, P < .001). Enteral intake between 0 and 21 days of life
(OR 0.66; 95% CI 0.53, 0.81, P < .0001) and oxygen therapy (OR 1.05; 95% CI 1.01,
1.09; P = .030) were identified as the best independent predictors of PNAC.
CONCLUSIONS: Enteral feeding remains the main factor for the prevention of PNAC,
whereas small for gestational age infants do not have a higher risk of PNAC.
KW - nutrition associated cholestasis
KW - nutrition associated cholestasis
UR - http://hdl.handle.net/10807/5512
M3 - Article
SN - 0022-3476
SP - 575
EP - 579
JO - THE JOURNAL OF PEDIATRICS
JF - THE JOURNAL OF PEDIATRICS
ER -