TY - JOUR
T1 - Preoperative treatment and surgery in gastric cancer: friends or foes?
AU - D'Ugo, Domenico
AU - Rausei, Stefano
AU - Biondi, Alberto
AU - Persiani, Roberto
PY - 2009
Y1 - 2009
N2 - Until 2006, most reports of preoperative (neoadjuvant) treatments for gastric carcinoma were inconclusive and produced confusing results due to inhomogeneous treatment regimens, selection of patients, and response assessment. Since publication of the results from the MAGIC trial, substantial scientific evidence has suggested the benefits of perioperative (preoperative and postoperative) chemotherapy to locally advanced gastric cancer. To date, this phase III trial, coupled with preliminary data from other published reports on neoadjuvant chemotherapy and radiotherapy, supports the theoretical advantages of preoperative treatment for gastric carcinoma, thus introducing the concept of delayed surgery. Neoadjuvant treatment of resectable, locally advanced tumours might improve patients' outcomes and postpone the need for curative resection, but it also exposes patients to the risk of tumour progression.
AB - Until 2006, most reports of preoperative (neoadjuvant) treatments for gastric carcinoma were inconclusive and produced confusing results due to inhomogeneous treatment regimens, selection of patients, and response assessment. Since publication of the results from the MAGIC trial, substantial scientific evidence has suggested the benefits of perioperative (preoperative and postoperative) chemotherapy to locally advanced gastric cancer. To date, this phase III trial, coupled with preliminary data from other published reports on neoadjuvant chemotherapy and radiotherapy, supports the theoretical advantages of preoperative treatment for gastric carcinoma, thus introducing the concept of delayed surgery. Neoadjuvant treatment of resectable, locally advanced tumours might improve patients' outcomes and postpone the need for curative resection, but it also exposes patients to the risk of tumour progression.
KW - Antineoplastic Agents
KW - Clinical Trials as Topic
KW - Combined Modality Therapy
KW - Digestive System Surgical Procedures
KW - Humans
KW - Neoadjuvant Therapy
KW - Stomach Neoplasms
KW - Antineoplastic Agents
KW - Clinical Trials as Topic
KW - Combined Modality Therapy
KW - Digestive System Surgical Procedures
KW - Humans
KW - Neoadjuvant Therapy
KW - Stomach Neoplasms
UR - http://hdl.handle.net/10807/31533
U2 - 10.1016/S1470-2045(09)70021-X
DO - 10.1016/S1470-2045(09)70021-X
M3 - Article
SN - 1470-2045
VL - 10
SP - 191
EP - 195
JO - The Lancet Oncology
JF - The Lancet Oncology
ER -