Preoperative radiotherapy and IORT in resectable rectal cancer at high risk for local recurrence

F Crucitti, Carlo Ratto, Luigi Sofo, G Battista Doglietto, Rocco Domenico Alfonso Bellantone, Maurizio Bossola, Liliana Sollazzi, Maria Antonietta Crea, Fm Vecchio, Alessia Piermattei

Risultato della ricerca: Contributo in rivistaArticolo in rivista

2 Citazioni (Scopus)


Over a 4-year period 35 patients with mid- (15 patients) and low (20 patients) rectal cancer clinically staged as T2 N1-2, T3 N0-2 underwent a protocol of combined surgery and radiotherapy. The protocol included: preoperative external beam radiotherapy (38 Gy, ICRU50); surgical resection; IORT on tumor bed (10 Gy). Toxicity of preoperative treatment was mild with a single case (2.9%) of grade 3 gastrointestinal toxicity. 18 patients underwent anterior resection and 17 abdominoperineal resection. Perioperative mortality and morbidity were 0% and 17.1% respectively. At a mean follow-up of 25 months all patients were alive. The single anastomotic recurrence observed was rescued with abdominoperineal resection.
Lingua originaleEnglish
pagine (da-a)190-196
Numero di pagine7
Stato di pubblicazionePubblicato - 1995


  • Endoscopy
  • Follow-Up Studies
  • Humans
  • Intraoperative Care
  • Neoplasm Recurrence, Local
  • Preoperative Care
  • Rectal Neoplasms
  • Risk Factors
  • Time Factors


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