Preoperative concomitant radiochemotherapy and IORT in locally advanced rectal cancer

F Crucitti; Luigi Sofo; Carlo Ratto; G Battista Doglietto; Rocco Domenico Alfonso Bellantone; P Nucera; Maurizio Bossola; Raffaella Ranieri; W Perilli; Luigi Azario

Preoperative concomitant radiochemotherapy and IORT in locally advanced rectal cancer

F Crucitti, Luigi Sofo, Carlo Ratto, G Battista Doglietto, Rocco Domenico Alfonso Bellantone, P Nucera, Maurizio Bossola, Raffaella Ranieri, W Perilli, Luigi Azario

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

34 patients with locally advanced (T4) or recurrent rectal cancer have been treated with: 1. external beam radiotherapy (45-48 Gy) + 5FU(1000 mg/m2/daily iv continuous infusion day 1-4) + MMC (10 mg/m2/daily iv, day 1); 2. surgical resection (if feasible) + IORT (10-15 Gy); 3. adjuvant chemotherapy (5FU+leucovorin, 6-8 cycles). Grade 3 acute hematological toxicity was observed in 1 case only. 23 of 34 patients underwent radical surgery. Perioperative mortality and morbidity was 0% and 17% respectively. In the 23 operated patients with a mean follow-up of 18.6 months there were 2 local recurrences, 5 blood metastases, (1 death of disease). 16 patients were shown to be NED (3-36 months).

Lingua originale	English
pagine (da-a)	197-207
Numero di pagine	11
Rivista	RAYS
Volume	20
Stato di pubblicazione	Pubblicato - 1995

Keywords

Antibiotics, Antineoplastic
Antidotes
Antimetabolites, Antineoplastic
Chemotherapy, Adjuvant
Combined Modality Therapy
Fluorouracil
Follow-Up Studies
Humans
Leucovorin
Lymph Node Excision
Mitomycin
Neoplasm Recurrence, Local
Postoperative Care
Preoperative Care
Radiotherapy Dosage
Rectal Neoplasms
Time Factors

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title = "Preoperative concomitant radiochemotherapy and IORT in locally advanced rectal cancer",

abstract = "34 patients with locally advanced (T4) or recurrent rectal cancer have been treated with: 1. external beam radiotherapy (45-48 Gy) + 5FU(1000 mg/m2/daily iv continuous infusion day 1-4) + MMC (10 mg/m2/daily iv, day 1); 2. surgical resection (if feasible) + IORT (10-15 Gy); 3. adjuvant chemotherapy (5FU+leucovorin, 6-8 cycles). Grade 3 acute hematological toxicity was observed in 1 case only. 23 of 34 patients underwent radical surgery. Perioperative mortality and morbidity was 0% and 17% respectively. In the 23 operated patients with a mean follow-up of 18.6 months there were 2 local recurrences, 5 blood metastases, (1 death of disease). 16 patients were shown to be NED (3-36 months).",

keywords = "Antibiotics, Antineoplastic, Antidotes, Antimetabolites, Antineoplastic, Chemotherapy, Adjuvant, Combined Modality Therapy, Fluorouracil, Follow-Up Studies, Humans, Leucovorin, Lymph Node Excision, Mitomycin, Neoplasm Recurrence, Local, Postoperative Care, Preoperative Care, Radiotherapy Dosage, Rectal Neoplasms, Time Factors, Antibiotics, Antineoplastic, Antidotes, Antimetabolites, Antineoplastic, Chemotherapy, Adjuvant, Combined Modality Therapy, Fluorouracil, Follow-Up Studies, Humans, Leucovorin, Lymph Node Excision, Mitomycin, Neoplasm Recurrence, Local, Postoperative Care, Preoperative Care, Radiotherapy Dosage, Rectal Neoplasms, Time Factors",

author = "F Crucitti and Luigi Sofo and Carlo Ratto and {Battista Doglietto}, G and Bellantone, {Rocco Domenico Alfonso} and P Nucera and Maurizio Bossola and Raffaella Ranieri and W Perilli and Luigi Azario",

year = "1995",

language = "English",

volume = "20",

pages = "197--207",

journal = "RAYS",

issn = "0390-7740",

publisher = "Ecoedizioni Internazionali Srl:Via Cola Di Rienzo 28, I 00192 Rome Italy:011 39 06 5501601, EMAIL: [email protected], Fax: 011 39 06 5501601",

}

TY - JOUR

T1 - Preoperative concomitant radiochemotherapy and IORT in locally advanced rectal cancer

AU - Crucitti, F

AU - Sofo, Luigi

AU - Ratto, Carlo

AU - Battista Doglietto, G

AU - Bellantone, Rocco Domenico Alfonso

AU - Nucera, P

AU - Bossola, Maurizio

AU - Ranieri, Raffaella

AU - Perilli, W

AU - Azario, Luigi

PY - 1995

Y1 - 1995

N2 - 34 patients with locally advanced (T4) or recurrent rectal cancer have been treated with: 1. external beam radiotherapy (45-48 Gy) + 5FU(1000 mg/m2/daily iv continuous infusion day 1-4) + MMC (10 mg/m2/daily iv, day 1); 2. surgical resection (if feasible) + IORT (10-15 Gy); 3. adjuvant chemotherapy (5FU+leucovorin, 6-8 cycles). Grade 3 acute hematological toxicity was observed in 1 case only. 23 of 34 patients underwent radical surgery. Perioperative mortality and morbidity was 0% and 17% respectively. In the 23 operated patients with a mean follow-up of 18.6 months there were 2 local recurrences, 5 blood metastases, (1 death of disease). 16 patients were shown to be NED (3-36 months).

AB - 34 patients with locally advanced (T4) or recurrent rectal cancer have been treated with: 1. external beam radiotherapy (45-48 Gy) + 5FU(1000 mg/m2/daily iv continuous infusion day 1-4) + MMC (10 mg/m2/daily iv, day 1); 2. surgical resection (if feasible) + IORT (10-15 Gy); 3. adjuvant chemotherapy (5FU+leucovorin, 6-8 cycles). Grade 3 acute hematological toxicity was observed in 1 case only. 23 of 34 patients underwent radical surgery. Perioperative mortality and morbidity was 0% and 17% respectively. In the 23 operated patients with a mean follow-up of 18.6 months there were 2 local recurrences, 5 blood metastases, (1 death of disease). 16 patients were shown to be NED (3-36 months).

KW - Antibiotics, Antineoplastic

KW - Antidotes

KW - Antimetabolites, Antineoplastic

KW - Chemotherapy, Adjuvant

KW - Combined Modality Therapy

KW - Fluorouracil

KW - Follow-Up Studies

KW - Humans

KW - Leucovorin

KW - Lymph Node Excision

KW - Mitomycin

KW - Neoplasm Recurrence, Local

KW - Postoperative Care

KW - Preoperative Care

KW - Radiotherapy Dosage

KW - Rectal Neoplasms

KW - Time Factors

KW - Antibiotics, Antineoplastic

KW - Antidotes

KW - Antimetabolites, Antineoplastic

KW - Chemotherapy, Adjuvant

KW - Combined Modality Therapy

KW - Fluorouracil

KW - Follow-Up Studies

KW - Humans

KW - Leucovorin

KW - Lymph Node Excision

KW - Mitomycin

KW - Neoplasm Recurrence, Local

KW - Postoperative Care

KW - Preoperative Care

KW - Radiotherapy Dosage

KW - Rectal Neoplasms

KW - Time Factors

UR - http://hdl.handle.net/10807/11921

M3 - Article

SN - 0390-7740

VL - 20

SP - 197

EP - 207

JO - RAYS

JF - RAYS

ER -

Preoperative concomitant radiochemotherapy and IORT in locally advanced rectal cancer

Abstract

Keywords

OSS delle Nazioni Unite

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