Preoperative concomitant radiochemotherapy and IORT in locally advanced rectal cancer

Luigi Sofo, Carlo Ratto, Rocco Domenico Alfonso Bellantone, Maurizio Bossola, Luigi Azario, Raffaella Ranieri, F Crucitti, G Battista Doglietto, P Nucera, W Perilli

Risultato della ricerca: Contributo in rivistaArticolo in rivista


34 patients with locally advanced (T4) or recurrent rectal cancer have been treated with: 1. external beam radiotherapy (45-48 Gy) + 5FU(1000 mg/m2/daily iv continuous infusion day 1-4) + MMC (10 mg/m2/daily iv, day 1); 2. surgical resection (if feasible) + IORT (10-15 Gy); 3. adjuvant chemotherapy (5FU+leucovorin, 6-8 cycles). Grade 3 acute hematological toxicity was observed in 1 case only. 23 of 34 patients underwent radical surgery. Perioperative mortality and morbidity was 0% and 17% respectively. In the 23 operated patients with a mean follow-up of 18.6 months there were 2 local recurrences, 5 blood metastases, (1 death of disease). 16 patients were shown to be NED (3-36 months).
Lingua originaleEnglish
pagine (da-a)197-207
Numero di pagine11
Stato di pubblicazionePubblicato - 1995


  • Antibiotics, Antineoplastic
  • Antidotes
  • Antimetabolites, Antineoplastic
  • Chemotherapy, Adjuvant
  • Combined Modality Therapy
  • Fluorouracil
  • Follow-Up Studies
  • Humans
  • Leucovorin
  • Lymph Node Excision
  • Mitomycin
  • Neoplasm Recurrence, Local
  • Postoperative Care
  • Preoperative Care
  • Radiotherapy Dosage
  • Rectal Neoplasms
  • Time Factors


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