Preliminary results of a counselling programme for fertility preservation in female cancer patients: The experience of the GEMME DORMIENTI network

Stefan Hohaus, Annarosa Cuccaro, Mariavita Ciccarone, Alessandro Pulsoni, Paola Cavaceppi, Simona Franzò, Raffaella Fabbri, Laura Cudillo, Roberta Battistini, Alice Di Rocco, Ombretta Annibali, Maria Christina Cox, Ida Provenzano, Elisabetta Abruzzese, Daniela Renzi, Cristiano Tesei, Paola Anticoli Borza, Alessandro Andriani, Gianna Maria D'Elia, Antonio FacchianoPaolo Marchetti, Maria Cantonetti

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

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Abstract

Objective: To describe a population of patients referred for fertility preservation (FP), how to efficiently provide FP care, and how FP care changed over time. Methods: This longitudinal observational study enrolled 281 female cancer patients referred between 2013 and 2016 to the non-profit organisation Gemme Dormienti ONLUS (GD) for FP care. All patients underwent the same battery of instrumental and laboratory diagnostic tests. GnRHa therapy was started at least seven days before CTh treatment. Results: From 2013 to 2016, we observed a progressive increase in the number of patients referred for FP care. Out of 251 eligible patients, 135 patients were treated with GnRHa only, and 72 patients underwent GnRHa therapy and cryopreservation. The median time from GD referral to oocyte and ovarian tissue cryopreservation was 11 and 5 days respectively. Tissue cryopreservation requests increased during our study period (from four cases in 2013 to 17 cases in 2016). During follow-up, 17β-estradiol and FSH levels were significantly increased (p <.0001), and AMH levels were significantly decreased (p <.0001). Conclusion: The rapid increase in the number of patients who requested FP care and in the complexity of FP procedures overtime reflects the need to improve quality of life for cancer patients.
Lingua originaleEnglish
pagine (da-a)e13174-N/A
Numero di pagine10
RivistaEuropean Journal of Cancer Care
Volume29
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • Lymphoma
  • fertility preservation

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