TY - JOUR
T1 - Pregnancy-Related Complications in Women with Recurrent Pregnancy Loss: A Prospective Cohort Study
AU - Ticconi, Carlo
AU - Pietropolli, Adalgisa
AU - Nicastri, Elena
AU - Chiaramonte, Carlo
AU - Piccione, Emilio
AU - Scambia, Giovanni
AU - Di Simone, Nicoletta
PY - 2020
Y1 - 2020
N2 - The aim of this prospective cohort study was to determine whether women with recurrent pregnancy loss (RPL) have an increased risk of pregnancy complications compared to normal pregnant women. A total of 1092 singleton pregnancies were followed, 431 in women with RPL and 661 in
normal healthy women. The prevalence of the following complications was observed: threatened miscarriage, miscarriage, cervical insuciency, chromosomal/genetic abnormalities, fetal anomalies, oligohydramnios, polyhydramnios, fetal growth restriction, intrauterine fetal death, gestational
diabetes mellitus (GDM), preeclampsia, placenta previa, abruptio placentae, pregnancy-related liver disorders, and preterm premature rupture of the membranes. The odds ratio and 95% CI for each pregnancy complication considered were determined by comparing women with RPL and normal
healthy women. Women with RPL had an overall rate of pregnancy complications higher than normal women (OR = 4.37; 95% CI: 3.353–5.714; p < 0.0001). Their risk was increased for nearly all the conditions considered. They also had an increased risk of multiple concomitant pregnancy
complications (OR = 4.64; 95% CI: 3.10–6.94, p < 0.0001). Considering only women with RPL, women with 3 losses had a higher risk of pregnancy complications than women with two losses (OR = 1.269; 95% CI: 1.112–2.386, p < 0.02). No dierences were found in the overall risk of pregnancy
complications according to the type, explained or unexplained, of RPL. Women with secondary RPL had an increased risk of GDM than women with primary RPL. Pregnancy in women with RPL should be considered at high risk.
AB - The aim of this prospective cohort study was to determine whether women with recurrent pregnancy loss (RPL) have an increased risk of pregnancy complications compared to normal pregnant women. A total of 1092 singleton pregnancies were followed, 431 in women with RPL and 661 in
normal healthy women. The prevalence of the following complications was observed: threatened miscarriage, miscarriage, cervical insuciency, chromosomal/genetic abnormalities, fetal anomalies, oligohydramnios, polyhydramnios, fetal growth restriction, intrauterine fetal death, gestational
diabetes mellitus (GDM), preeclampsia, placenta previa, abruptio placentae, pregnancy-related liver disorders, and preterm premature rupture of the membranes. The odds ratio and 95% CI for each pregnancy complication considered were determined by comparing women with RPL and normal
healthy women. Women with RPL had an overall rate of pregnancy complications higher than normal women (OR = 4.37; 95% CI: 3.353–5.714; p < 0.0001). Their risk was increased for nearly all the conditions considered. They also had an increased risk of multiple concomitant pregnancy
complications (OR = 4.64; 95% CI: 3.10–6.94, p < 0.0001). Considering only women with RPL, women with 3 losses had a higher risk of pregnancy complications than women with two losses (OR = 1.269; 95% CI: 1.112–2.386, p < 0.02). No dierences were found in the overall risk of pregnancy
complications according to the type, explained or unexplained, of RPL. Women with secondary RPL had an increased risk of GDM than women with primary RPL. Pregnancy in women with RPL should be considered at high risk.
KW - pregnancy complications
KW - recurrent pregnancy loss, reproductive health
KW - pregnancy complications
KW - recurrent pregnancy loss, reproductive health
UR - http://hdl.handle.net/10807/161971
U2 - 10.3390/jcm9092833
DO - 10.3390/jcm9092833
M3 - Article
SN - 2077-0383
SP - 1
EP - 12
JO - Journal of Clinical Medicine
JF - Journal of Clinical Medicine
ER -