Pregnancy Outcome Following Exposure to Topical Retinoids: A Multicenter Prospective Study

A Panchaud, C Csajka, P Merlob, C Schaefer, M Berlin, Marco De Santis, T Vial, A Ieri, H Malm, G Eleftheriou, B Stahl, P Rousso, U Winterfeld, Le Rothuizen, T. Buclin

Risultato della ricerca: Contributo in rivistaArticolo in rivista

30 Citazioni (Scopus)


Concerns have been raised about the use of topical retinoids since the publication of isolated cases of characteristic retinoid embryopathy, originally described after oral use. A collaborative study of the European Network of Teratology Information Services was carried out to evaluate the rate of congenital malformations following first-trimester topical retinoid exposure. A population of 235 exposed pregnant women was compared with 444 controls. No significant differences were observed between groups with regard to the rates of spontaneous abortion (odds ratio [95% confidence interval], 1.5 [0.8-2.7]), minor birth defects (1.3 [0.4-3.7]), and major birth defects (1.8 [0.6-5.4]). No child showed features of retinoid embryopathy. The rate of elective termination in the exposed group was increased 3-fold (3.4 [1.5-7.8]). In conclusion, these results do not suggest an increased risk of retinoid embryopathy. However, according to current knowledge, topical retinoids cannot be advised for use during pregnancy because their risk/benefit ratio remains questionable.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
Stato di pubblicazionePubblicato - 2011


  • pregnancy
  • retinoids


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