Pregabalin for alcohol dependence: a critical review of the literature

Luigi Janiri, Riccardo Guglielmo, Giovanni Martinotti, Massimo Clerici

Risultato della ricerca: Contributo in rivistaArticolo in rivista

35 Citazioni (Scopus)

Abstract

Alcohol dependence represents a severe pathological disorder associated with a significant rate of morbidity and mortality. To date, limited pharmacological agents exist to treat this disorder, and there is a growing interest for new therapies. In this context, pregabalin represents a promising strategy. Pregabalin, like gabapentin, selectively binds to the α(2)δsubunit of voltage-gated calcium channels, inhibiting release of excessive levels of excitatory neurotransmitters. The main focus of this review is the clinical use of pregabalin in alcoholic patients, but the authors also reported some data about chemistry, pharmacology, and pharmacokinetics of this drug.
Lingua originaleEnglish
pagine (da-a)947-957
Numero di pagine11
RivistaAdvances in Therapy
Volume29
DOI
Stato di pubblicazionePubblicato - 2012

Keywords

  • Adult
  • Aged
  • Alcoholism
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Randomized Controlled Trials as Topic
  • Recurrence
  • Risk Assessment
  • Severity of Illness Index
  • Substance Withdrawal Syndrome
  • Treatment Outcome
  • Young Adult
  • gamma-Aminobutyric Acid

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