Predictors of mortality in multidrug-resistant Klebsiella pneumoniae bloodstream infections

Mario Tumbarello, Pierluigi Viale, Maddalena Giannella, Russell Lewis, Nicola Petrosillo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

59 Citazioni (Scopus)

Abstract

The dramatic increase of antibiotic resistance in Klebsiella pneumoniae has been associated with fatal outcomes. First, bloodstream infections (BSIs) caused by extended-spectrum β-lactamases (ESBL) Enterobacteriaceae have been associated with treatment failure, more recently BSIs caused by carbapenem-resistant K. pneumoniae (CR-KP) have been reported to be fatal in approximately 50% of cases. Severity of underlying disease, intensive care unit stay at infection onset, infection with ESBL or CR-KP strain and delay in administration of appropriate therapy are among the most common risk factors for mortality in patients with K. pneumoniae BSI, while infection source control and early appropriate antimicrobial treatment have been associated with survival. Thus, risk assessment for ESBL and/or CR-KP is mandatory in patients with suspicion of K. pneumoniae BSI. Here, we examine current evidence regarding risk factors for mortality in patients with K. pneumoniae BSI and address the issue of a risk prediction model for CR-KP BSI.
Lingua originaleEnglish
pagine (da-a)1053-1063
Numero di pagine11
RivistaExpert Review of Anti-Infective Therapy
Volume11
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • klebsiella
  • mortality

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