Predictors for atrial fibrillation detection after cryptogenic stroke: Results from CRYSTAL AF

Vincent N. Thijs, Johannes Brachmann, Carlos A. Morillo, Rod S. Passman, Tommaso Sanna, Richard A. Bernstein, Hans-Christoph Diener, Vincenzo Di Lazzaro, Marilyn M. Rymer, Laurence Hogge, Tyson B. Rogers, Paul D. Ziegler, Manish D. Assar

Risultato della ricerca: Contributo in rivistaArticolo in rivista

81 Citazioni (Scopus)


Objective: We assessed predictors of atrial fibrillation (AF) in cryptogenic stroke (CS) or transient ischemic attack (TIA) patients who received an insertable cardiac monitor (ICM). Methods: We studied patients with CS/TIA who were randomized to ICM within the CRYSTAL AF study. We assessed whether age, sex, race, body mass index, type and severity of index ischemic event, CHADS2 score, PR interval, and presence of diabetes, hypertension, congestive heart failure, or patent foramen ovale and premature atrial contractions predicted AF development within the initial 12 and 36 months of follow-up using Cox proportional hazards models. Results: Among 221 patients randomized to ICM (age 61.6 ± 11.4 years, 64% male), AF episodes were detected in 29 patients within 12 months and 42 patients at 36 months. Significant univariate predictors of AF at 12 months included age (hazard ratio [HR] per decade 2.0 [95% confidence interval 1.4-2.8], p 5 0.002), CHADS2 score (HR 1.9 per one point [1.3-2.8], p = 0.008), PR interval (HR 1.3 per 10 milliseconds [1.2-1.4], p < 0.0001), premature atrial contractions (HR 3.9 for >123 vs 0 [1.3-12.0], p = 0.009 across quartiles), and diabetes (HR 2.3 [1.0-5.2], p < 0.05). In multivariate analysis, age (HR per decade 1.9 [1.3-2.8], p = 0.0009) and PR interval (HR 1.3 [1.2-1.4], p < 0.0001) remained significant and together yielded an area under the receiver operating characteristic curve of 0.78 (0.70-0.85). The same predictors were found at 36 months. Conclusion: Increasing age and a prolonged PR interval at enrollment were independently associated with an increased AF incidence in CS patients. However, they offered only moderate predictive ability in determining which CS patients had AF detected by the ICM.
Lingua originaleEnglish
pagine (da-a)261-269
Numero di pagine9
Stato di pubblicazionePubblicato - 2016


  • Aged
  • Atrial Fibrillation
  • Comorbidity
  • Echocardiography
  • Electrocardiography
  • Female
  • Follow-Up Studies
  • Humans
  • Ischemic Attack, Transient
  • Male
  • Middle Aged
  • Monitoring, Physiologic
  • Prognosis
  • Randomized Controlled Trials as Topic
  • Stroke


Entra nei temi di ricerca di 'Predictors for atrial fibrillation detection after cryptogenic stroke: Results from CRYSTAL AF'. Insieme formano una fingerprint unica.

Cita questo