Predictive Value of Endobronchial Ultrasound Strain Elastography in Mediastinal Lymph Node Staging: The E-Predict Multicenter Study Results

Roel Lambertus Johannes Verhoeven, Rocco Trisolini, Fausto Leoncini, Piero Candoli, Michela Bezzi, Alessandro Messi, Mark Krasnik, Chris L. De Korte, Jouke T. Annema, Erik H.F.M. Van Der Heijden

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Background: Systematic assessment of lymph node status by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is indicated in (suspected) lung cancer. Sampling is herein guided by nodal size and FDG-PET characteristics. Ultrasound strain elastography (SE) might further improve risk stratification. By imaging tissue deformation over time, SE computes relative tissue strain. In several tissues, a lower strain (deformation) has been associated with a higher likelihood of malignancy. Objectives: To assess if EBUS-SE can independently help predict malignancy, and when combined with size and FDG uptake information. Methods: This multicenter (n = 5 centers) prospective trial included patients with suspected or proven lung cancer using a standardized measurement protocol. Cytopathology combined with surgery or follow-up imaging (>6 months) were used as reference standard. Results: Between June 2016 and July 2018, 327 patients and 525 lymph nodes were included (mean size 12.3 mm, malignancy prevalence 0.48). EBUS-SE had an overall AUC of 0.77. A mean strain <115 (range 0-255) showed 90% sensitivity, 43% specificity, 60% positive predictive value, and 82% negative predictive value. Combining EBUS-SE (<115) with size (<8 mm) and FDG-PET information into a risk stratification algorithm increased the accuracy. Combining size and SE showed that the 48% a priori chance of malignancy changed to 11 and 70% in double negative or positive nodes, respectively. In the subset where FDG-PET was available (n = 370), triple negative and positive nodes went from a 42% a priori chance of malignancy to 9 and 73%, respectively. Conclusions: EBUS-SE can help predict lymph node malignancy and may be useful for risk stratification when combined with size and PET information. (c) 2020 The Author(s) Published by S. Karger AG, Basel
Lingua originaleEnglish
pagine (da-a)484-492
Numero di pagine9
RivistaRespiration
Volume99
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • Bronchoscopy
  • Endobronchial ultrasound
  • Endobronchial ultrasound-transbronchial needle aspiration
  • Ultrasound elastography
  • Lung cancer staging
  • Strain elastography
  • Esophageal ultrasound

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