TY - JOUR
T1 - Prediction of histological grade of endometrial cancer by means of MRI
AU - Bonatti, Matteo
AU - Pedrinolla, Beatrice
AU - Cybulski, Adam Jerzy
AU - Lombardo, Fabio
AU - Negri, Giovanni
AU - Messini, Sergio
AU - Tagliaferri, Tiziana
AU - Manfredi, Riccardo
AU - Bonatti, Giampietro
PY - 2018
Y1 - 2018
N2 - Objectives: To evaluate the ability of MRI in predicting histological grade of endometrial cancer (EC). Methods: IRB-approved retrospective study; requirement for informed consent was waived. 90 patients with histologically proven EC who underwent preoperative MRI and surgery at our Institution between Sept2011 and Nov2016 were included. Myometrial invasion (50%) was assessed. Neoplasm and uterus volumes were estimated according to the ellipsoid formula; neoplasm/uterus volume ratio (N/U) was calculated. ADC maps were generated and histogram analysis was performed using commercially available software. MRI parameters were compared with the definitive histological grade (G1 = 28 patients, G2 = 29, G3 = 33) using ANOVA and Tukey-Kramer tests. Results: Deep myometrial invasion was significantly more frequent in G2-G3 lesions than in G1 ones (p < 0,005). N/U ratio was significantly higher for high-grade neoplasms (mean 0,08 for G1, 0,16 for G2 and 0,21 in G3; P = 0,002 for G1 vs. G2-G3); a cut off value of 0,13 enabled to distinguish G1 from G2-G3 lesions with 50% sensibility and 89% specificity. ADC values didn't show any statistically significant correlation with tumour grade. Conclusions: N/U ratio >0.13 and deep myometrial invasion are significantly correlated with high grade EC, whereas ADC values are not useful for predicting EC grade.
AB - Objectives: To evaluate the ability of MRI in predicting histological grade of endometrial cancer (EC). Methods: IRB-approved retrospective study; requirement for informed consent was waived. 90 patients with histologically proven EC who underwent preoperative MRI and surgery at our Institution between Sept2011 and Nov2016 were included. Myometrial invasion (50%) was assessed. Neoplasm and uterus volumes were estimated according to the ellipsoid formula; neoplasm/uterus volume ratio (N/U) was calculated. ADC maps were generated and histogram analysis was performed using commercially available software. MRI parameters were compared with the definitive histological grade (G1 = 28 patients, G2 = 29, G3 = 33) using ANOVA and Tukey-Kramer tests. Results: Deep myometrial invasion was significantly more frequent in G2-G3 lesions than in G1 ones (p < 0,005). N/U ratio was significantly higher for high-grade neoplasms (mean 0,08 for G1, 0,16 for G2 and 0,21 in G3; P = 0,002 for G1 vs. G2-G3); a cut off value of 0,13 enabled to distinguish G1 from G2-G3 lesions with 50% sensibility and 89% specificity. ADC values didn't show any statistically significant correlation with tumour grade. Conclusions: N/U ratio >0.13 and deep myometrial invasion are significantly correlated with high grade EC, whereas ADC values are not useful for predicting EC grade.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Diffusion magnetic resonance imaging
KW - Endometrial Neoplasms
KW - Endometrial neoplasms
KW - Endometrium
KW - Female
KW - Humans
KW - Magnetic Resonance Imaging
KW - Magnetic resonance imaging
KW - Middle Aged
KW - Neoplasm Grading
KW - Neoplasm grading
KW - Radiology, Nuclear Medicine and Imaging
KW - Retrospective Studies
KW - Sensitivity and Specificity
KW - Uterus
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Diffusion magnetic resonance imaging
KW - Endometrial Neoplasms
KW - Endometrial neoplasms
KW - Endometrium
KW - Female
KW - Humans
KW - Magnetic Resonance Imaging
KW - Magnetic resonance imaging
KW - Middle Aged
KW - Neoplasm Grading
KW - Neoplasm grading
KW - Radiology, Nuclear Medicine and Imaging
KW - Retrospective Studies
KW - Sensitivity and Specificity
KW - Uterus
UR - http://hdl.handle.net/10807/150651
UR - http://www.elsevier.com/locate/ejrad
U2 - 10.1016/j.ejrad.2018.04.008
DO - 10.1016/j.ejrad.2018.04.008
M3 - Article
SN - 0720-048X
VL - 103
SP - 44
EP - 50
JO - European Journal of Radiology
JF - European Journal of Radiology
ER -