TY - JOUR
T1 - Predicting outcomes in radiation oncology-multifactorial decision support systems
AU - Valentini, Vincenzo
AU - Granone, Pierluigi
AU - Lambin, Philippe
AU - Van Stiphout, Ruud G.P.M.
AU - Starmans, Maud H.W.
AU - Rios-Velazquez, Emmanuel
AU - Nalbantov, Georgi
AU - Aerts, Hugo J.W.L.
AU - Roelofs, Erik
AU - Van Elmpt, Wouter
AU - Boutros, Paul C.
AU - De Ruysscher, Dirk
AU - Dekker, Andre
PY - 2012
Y1 - 2012
N2 - With the emergence of individualized medicine and the increasing amount and complexity of available medical data, a growing need exists for the development of clinical decision-support systems based on prediction models of treatment outcome. In radiation oncology, these models combine both predictive and prognostic data factors from clinical, imaging, molecular and other sources to achieve the highest accuracy to predict tumour response and follow-up event rates. In this Review, we provide an overview of the factors that are correlated with outcome-including survival, recurrence patterns and toxicity-in radiation oncology and discuss the methodology behind the development of prediction models, which is a multistage process. Even after initial development and clinical introduction, a truly useful predictive model will be continuously re-evaluated on different patient datasets from different regions to ensure its population-specific strength. In the future, validated decision-support systems will be fully integrated in the clinic, with data and knowledge being shared in a standardized, instant and global manner.
AB - With the emergence of individualized medicine and the increasing amount and complexity of available medical data, a growing need exists for the development of clinical decision-support systems based on prediction models of treatment outcome. In radiation oncology, these models combine both predictive and prognostic data factors from clinical, imaging, molecular and other sources to achieve the highest accuracy to predict tumour response and follow-up event rates. In this Review, we provide an overview of the factors that are correlated with outcome-including survival, recurrence patterns and toxicity-in radiation oncology and discuss the methodology behind the development of prediction models, which is a multistage process. Even after initial development and clinical introduction, a truly useful predictive model will be continuously re-evaluated on different patient datasets from different regions to ensure its population-specific strength. In the future, validated decision-support systems will be fully integrated in the clinic, with data and knowledge being shared in a standardized, instant and global manner.
KW - pneumonectomy
KW - pneumonectomy
UR - http://hdl.handle.net/10807/39525
U2 - 10.1038/nrclinonc.2012.196
DO - 10.1038/nrclinonc.2012.196
M3 - Article
VL - 10
SP - 27
EP - 40
JO - Nature Reviews Clinical Oncology
JF - Nature Reviews Clinical Oncology
SN - 1759-4774
ER -