Predicting In-Hospital Mortality in COVID-19 Older Patients with Specifically Developed Scores

Marcello Covino, Giuseppe De Matteis, Maria Livia Burzo, Andrea Russo, Elia Forte, Annamaria Carnicelli, Andrea Piccioni, Benedetta Simeoni, Antonio Gasbarrini, Francesco Franceschi, Claudio Sandroni

Risultato della ricerca: Contributo in rivistaArticolo in rivista

3 Citazioni (Scopus)


Background/Objectives Several scoring systems have been specifically developed for risk stratification in COVID-19 patients.Design We compared, in a cohort of confirmed COVID-19 older patients, three specifically developed scores with a previously established early warning score. Main endpoint was all causes in-hospital death.Setting This is a single-center, retrospective observational study, conducted in the Emergency Department (ED) of an urban teaching hospital, referral center for COVID-19.Participants We reviewed the clinical records of the confirmed COVID-19 patients aged 60 years or more consecutively admitted to our ED over a 6-week period (March 1st to April 15th, 2020). A total of 210 patients, aged between 60 and 98 years were included in the study cohort.Measurements International Severe Acute Respiratory Infection Consortium Clinical Characterization Protocol-Coronavirus Clinical Characterization Consortium (ISARIC-4C) score, COVID-GRAM Critical Illness Risk Score (COVID-GRAM), quick COVID-19 Severity Index (qCSI), National Early Warning Score (NEWS).Results Median age was 74 (67-82) and 133 (63.3%) were males. Globally, 42 patients (20.0%) deceased. All the score evaluated showed a fairly good predictive value with respect to in-hospital death. The ISARIC-4C score had the highest area under ROC curve (AUROC) 0.799 (0.738-0.851), followed by the COVID-GRAM 0.785 (0.723-0.838), NEWS 0.764 (0.700-0.819), and qCSI 0.749 (0.685-0.806). However, these differences were not statistical significant.Conclusion Among the evaluated scores, the ISARIC-4C and the COVID-GRAM, calculated at ED admission, had the best performance, although the qCSI had similar efficacy by evaluating only three items. However, the NEWS, already widely validated in clinical practice, had a similar performance and could be appropriate for older patients with COVID-19.
Lingua originaleEnglish
pagine (da-a)37-43
Numero di pagine7
RivistaJournal of the American Geriatrics Society
Stato di pubblicazionePubblicato - 2021


  • 4C
  • COVID‐19
  • GRAM
  • NEWS
  • qCSI


Entra nei temi di ricerca di 'Predicting In-Hospital Mortality in COVID-19 Older Patients with Specifically Developed Scores'. Insieme formano una fingerprint unica.

Cita questo