Preclinical evaluation of the novel 7-substituted camptothecin Namitecan (ST1968) in paediatric tumour models

Daniela Meco, Angela Maria Di Francesco, Filomena Pierri, Riccardo Riccardi, Federica Bucci, Claudio Pisano

Risultato della ricerca: Contributo in rivistaArticolo in rivista

9 Citazioni (Scopus)

Abstract

The present study aimed to evaluate the new water soluble camptothecin analogue Namitecan (ST1968) in preclinical paediatric tumour models of the nervous system comprehensive of neuroblastoma, primitive neuroectodermal tumours/PNET and medulloblastoma where the drug was compared to Irinotecan.
Lingua originaleEnglish
pagine (da-a)811-822
Numero di pagine12
RivistaCancer Chemotherapy and Pharmacology
Volume70
DOI
Stato di pubblicazionePubblicato - 2012

Keywords

  • Animals
  • Antineoplastic Agents, Phytogenic
  • Antineoplastic Combined Chemotherapy Protocols
  • Apoptosis
  • Blotting, Western
  • Camptothecin
  • Cell Cycle
  • Cell Line, Tumor
  • Cerebellar Neoplasms
  • Child
  • Comet Assay
  • DNA Damage
  • Drug Synergism
  • Humans
  • Medulloblastoma
  • Mice
  • Mice, Nude
  • Neuroblastoma
  • Neuroectodermal Tumors, Primitive
  • Platinum Compounds
  • Xenograft Model Antitumor Assays

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