Precision Phenomapping of Acute Coronary Syndromes to Improve Patient Outcomes

Felicita Andreotti, Filippo Crea, Giovanni Scambia, Adelaide Iervolino, Eliano Pio Navarese, Aldo Pietro Maggioni

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

cute coronary syndromes (ACS) are a global leading cause of death. These syndromes show heterogeneity in presentation, mechanisms, outcomes and responses to treatment. Precision medicine aims to identify and synthesize unique features in individuals, translating the acquired data into improved personalised interventions. Current precision treatments of ACS include immediate coronary revascularisation driven by ECG ST-segment elevation, early coronary angiography based on elevated blood cardiac troponins in patients without ST-segment elevation, and duration of intensified antithrombotic therapy according to bleeding risk scores. Phenotypically stratified analyses of multi-omic datasets are urgently needed to further refine and couple the diagnosis and treatment of these potentially life-threatening conditions. We provide definitions, examples and possible ways to advance precision treatments of ACS.
Lingua originaleEnglish
pagine (da-a)1755-N/A
RivistaJournal of Clinical Medicine
Volume10
DOI
Stato di pubblicazionePubblicato - 2021

Keywords

  • acute coronary syndromes
  • omic technologies
  • outcomes
  • phenomapping
  • precision
  • treatments

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