TY - JOUR
T1 - Practical indications for the management of non-melanoma skin cancer patients
AU - Di Stefani, Alessandro
AU - Del Regno, Laura
AU - Piccerillo, Alfredo
AU - Peris, Ketty
PY - 2017
Y1 - 2017
N2 - Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), together encompassed in the term non-melanoma skin cancers (NMSC), are the most common cancers among fair-skinned populations. Individuating accurate risk stratification of NMSC patients is crucial to select different options among various treatment strategies. The majority of low risk NM SCs are easily treated with surgery, offering excellent cure rates and cosmetic results. Other treatment modalities include physical destruction (curettage, cautery and cryotherapy), chemical destruction (photodynamic therapy and topical 5-flurouracil) and immunomodulatory therapy (topical imiquimod). However, there is a subset of "high-risk" NM SC characterized by prognostic factors associated to aggressive behavior, such as tumor location and size, clinical margins, histopathological variants, recurrence or previous treatment. These lesions need to be treated accordingly also by mean of adjuvant treatments. The contribution of a multidisciplinary team is necessary to appropriately manage patients affected by advanced NM SC. The aim of these practical indications is to provide a useful guidance for risk stratification of NMSC patients in clinical setting and for consequential treatment choice, resulting in individualized management strategies.
AB - Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), together encompassed in the term non-melanoma skin cancers (NMSC), are the most common cancers among fair-skinned populations. Individuating accurate risk stratification of NMSC patients is crucial to select different options among various treatment strategies. The majority of low risk NM SCs are easily treated with surgery, offering excellent cure rates and cosmetic results. Other treatment modalities include physical destruction (curettage, cautery and cryotherapy), chemical destruction (photodynamic therapy and topical 5-flurouracil) and immunomodulatory therapy (topical imiquimod). However, there is a subset of "high-risk" NM SC characterized by prognostic factors associated to aggressive behavior, such as tumor location and size, clinical margins, histopathological variants, recurrence or previous treatment. These lesions need to be treated accordingly also by mean of adjuvant treatments. The contribution of a multidisciplinary team is necessary to appropriately manage patients affected by advanced NM SC. The aim of these practical indications is to provide a useful guidance for risk stratification of NMSC patients in clinical setting and for consequential treatment choice, resulting in individualized management strategies.
KW - 2708
KW - Basal cell carcinoma
KW - Medicine (all)
KW - Skin neoplasms
KW - Squamous cell carcinoma
KW - 2708
KW - Basal cell carcinoma
KW - Medicine (all)
KW - Skin neoplasms
KW - Squamous cell carcinoma
UR - http://hdl.handle.net/10807/102124
UR - http://www.minervamedica.it/en/getpdf/e0sfo1poipyk2uoqhz8efkashefyal%252bmy3jqshpsu1s9wvsfd73eo3ranvokik5r9wu35bzvdrsshwc%252fndjjla%253d%253d/r23y2017n03a0286.pdf
U2 - 10.23736/S0392-0488.17.05588-2
DO - 10.23736/S0392-0488.17.05588-2
M3 - Article
SN - 0392-0488
VL - 152
SP - 286
EP - 294
JO - Giornale Italiano di Dermatologia e Venereologia
JF - Giornale Italiano di Dermatologia e Venereologia
ER -