Potential use of monoclonal antibodies in the diagnostic distinction of gynecomastia from breast carcinoma in men

Antonella Coli, Giulio Bigotti, M Mottolese, C Vitucci, P G Natali

Risultato della ricerca: Contributo in rivistaArticolo in rivista

4 Citazioni (Scopus)

Abstract

Immunohistochemical (IHC) assays using the monoclonal antibodies (MoAbs) B72.3 and B6.2, recognizing two distinct and independently expressed breast tumor-associated antigens (BTAAs), recently have been shown to significantly improve the accuracy of cytodiagnosis of breast nodules by fine-needle aspiration (FNA). To evaluate whether the same method may be useful diagnostically in distinguishing gynecomastia from breast cancer in men, a retrospective avidin-biotin immunoperoxidase assay study was performed on 50 cases of gynecomastia and 30 cases of breast carcinoma in men, using a panel of five MoAbs known to recognize different BTAAs. The results of this study demonstrated that MoAbs B1.1, HMFG2, and MBr1 displayed a strong reactivity with gynecomastia and carcinoma, but MoAbs B72.3 and B6.2 separated benign and malignant lesions in a high percentage of cases. When used in combination, the latter two reagents reacted with 96% of the carcinomas that were analyzed but labeled only 67% of gynecomastia cases. Thus, the conjoint use of these two reagents may enhance the use of FNA biopsy as a valuable tool in the presurgical diagnosis of breast nodules in men.
Lingua originaleEnglish
pagine (da-a)233-237
Numero di pagine5
RivistaAmerican Journal of Clinical Pathology
Volume96
Stato di pubblicazionePubblicato - 1991

Keywords

  • Adolescent
  • Adult
  • Aged
  • Antibodies, Monoclonal
  • Antigens
  • Breast Neoplasms
  • Carcinoma
  • Diagnosis, Differential
  • Gynecomastia
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Phenotype
  • Retrospective Studies
  • Staining and Labeling

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