TY - JOUR
T1 - Potential therapeutic role of microRNAs in ischemic heart disease
AU - Biasucci, Luigi Marzio
AU - Caroli, Annalisa
AU - Cardillo, Maria Teresa
PY - 2013
Y1 - 2013
N2 - Cardiovascular disease (CVD) is the most important cause of death and illness in the western world. Atherosclerosis constitutes the single most important contributor to CVD. miRNAs are small ribonucleic acids (RNAs) that negatively regulate gene expression on the post-transcriptional level by inhibiting mRNA translation or promoting mRNA degradation. Several studies demonstrated that miRNAs dysregulation have a key role in the disease process and, focusing on atherosclerotic disease, in every step of plaque formation and destabilization. These data suggest a possible therapeutic application of miRNA modulation, in particular dysregulated miRNAs can be modulated in disease process antagonizing miRNAs up-regulated and increasing miRNAs down-regulated. In this review we summarize the miRNA therapeutic techniques (antimiR, mimics, sponges, masking, and erasers) underlining their therapeutic advantages and evaluating their risks and challenges. In particular, the use of miRNA modulators as a therapeutic approach opens a novel and fascinating area of intervention in the therapy of ischemic heart disease. © 2013 Japanese College of Cardiology.
AB - Cardiovascular disease (CVD) is the most important cause of death and illness in the western world. Atherosclerosis constitutes the single most important contributor to CVD. miRNAs are small ribonucleic acids (RNAs) that negatively regulate gene expression on the post-transcriptional level by inhibiting mRNA translation or promoting mRNA degradation. Several studies demonstrated that miRNAs dysregulation have a key role in the disease process and, focusing on atherosclerotic disease, in every step of plaque formation and destabilization. These data suggest a possible therapeutic application of miRNA modulation, in particular dysregulated miRNAs can be modulated in disease process antagonizing miRNAs up-regulated and increasing miRNAs down-regulated. In this review we summarize the miRNA therapeutic techniques (antimiR, mimics, sponges, masking, and erasers) underlining their therapeutic advantages and evaluating their risks and challenges. In particular, the use of miRNA modulators as a therapeutic approach opens a novel and fascinating area of intervention in the therapy of ischemic heart disease. © 2013 Japanese College of Cardiology.
KW - AntimiR
KW - Cardiology and Cardiovascular Medicine
KW - Humans
KW - Ischemic heart disease
KW - MiRNA
KW - MicroRNAs
KW - Mimics
KW - Myocardial Ischemia
KW - Oligonucleotides, Antisense
KW - Therapeutic application
KW - AntimiR
KW - Cardiology and Cardiovascular Medicine
KW - Humans
KW - Ischemic heart disease
KW - MiRNA
KW - MicroRNAs
KW - Mimics
KW - Myocardial Ischemia
KW - Oligonucleotides, Antisense
KW - Therapeutic application
UR - http://hdl.handle.net/10807/99783
U2 - 10.1016/j.jjcc.2013.01.012
DO - 10.1016/j.jjcc.2013.01.012
M3 - Article
VL - 61
SP - 315
EP - 320
JO - Journal of cardiography. Supplement
JF - Journal of cardiography. Supplement
SN - 0914-5087
ER -