Potential role of APRIL as autocrine growth factor for megakaryocytopoiesis

Ruggero De Maria Marchiano, Désirée Bonci, Michael Hahne, Nadia Felli, Cesare Peschle

Risultato della ricerca: Contributo in rivistaArticolo in rivista

25 Citazioni (Scopus)

Abstract

A proliferation-inducing ligand (APRIL) is a new tumor necrosis factor family member implicated in tumor cell proliferation. We investigated the role of APRIL in megakaryocytopoiesis, a developmental hematopoietic process responsible for progenitor cell differentiation to megakaryoblasts and megakaryocytes, leading to platelet formation. APRIL is not expressed in CD34+ progenitor cells from healthy donors, but it is massively up-regulated during the proliferative phase of megakaryocytic cell differentiation. Exogenous APRIL expression in primary cells increases megakaryocytic cell growth, suggesting that APRIL acts as a proliferative factor in megakaryocytopoiesis. More importantly, neutralization of endogenous APRIL was able to dramatically reduce megakaryocyte expansion and platelet production. Thus, our data provide evidence that APRIL acts as a growth factor for terminal megakaryocytopoiesis and may promote physiologic platelet production. © 2004 by The American Society of Hematology.
Lingua originaleEnglish
pagine (da-a)3169-3172
Numero di pagine4
RivistaBlood
Volume104
DOI
Stato di pubblicazionePubblicato - 2004

Keywords

  • Autocrine Communication
  • Blood Platelets
  • Cell Division
  • Fetal Blood
  • Growth Substances
  • Hematology
  • Humans
  • Megakaryocytes
  • Nuclear Proteins

Fingerprint

Entra nei temi di ricerca di 'Potential role of APRIL as autocrine growth factor for megakaryocytopoiesis'. Insieme formano una fingerprint unica.

Cita questo