Posttransplant encapsulating peritoneal sclerosis, long-term success with everolimus and low-dose CNI: a case report

Jacopo Romagnoli, Franco Citterio, José Alberto Rodrigues Pedroso, Maria Paola Salerno, Evaldo Favi, Gionata Spagnoletti

Risultato della ricerca: Contributo in rivistaArticolo in rivista

6 Citazioni (Scopus)

Abstract

Encapsulating peritoneal sclerosis is a serious complication of peritoneal dialysis and can occur even after transplant. The gut is partially or totally enveloped by a thick fibrous membrane that leads to the formation of multiple sections containing intestinal loops contracted and reduced in volume. Exacerbation after renal transplantation is a very rare but sometimes dramatic condition. We report a patient who developed intestinal obstruction due to encapsulating peritoneal sclerosis 1 year after a deceased-donor kidney transplant. Treatment included laparotomy, small-bowel lengthening by release of adhesions, and high doses of corticosteroids. The patient received immunosuppressive therapy with a combination of low-dose cyclosporine, everolimus, and prednisone, unchanged except for a temporary steroid increase in the postoperative period. We report success with this combined surgical plus medical therapy, with no recurrence after 81 months of follow-up.
Lingua originaleEnglish
pagine (da-a)2368-2370
Numero di pagine3
RivistaTransplantation Proceedings
Volume46
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • Adult
  • Calcineurin Inhibitors
  • Cyclosporine
  • Drug Therapy, Combination
  • Everolimus
  • Female
  • Glucocorticoids
  • Humans
  • Immunosuppressive Agents
  • Intestinal Obstruction
  • Kidney Transplantation
  • Peritoneal Dialysis
  • Peritoneal Fibrosis
  • Prednisone
  • Sirolimus

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