Abstract
In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL-rslA mutant strain was significantly attenuated in a mouse model of infection.
Lingua originale | Inglese |
---|---|
pagine (da-a) | 2457-2461 |
Numero di pagine | 5 |
Rivista | Infection and Immunity |
Volume | 74 |
Numero di pubblicazione | 4 |
DOI | |
Stato di pubblicazione | Pubblicato - 2006 |
Pubblicato esternamente | Sì |
Keywords
- Animals
- Bacterial
- Base Sequence
- Gene Expression Regulation
- Inbred BALB C
- Inbred C57BL
- Inbred DBA
- Mice
- Molecular Sequence Data
- Mycobacterium tuberculosis
- Post-Translational
- Protein Processing
- Pulmonary
- Sigma Factor
- Tuberculosis
- Virulence Factors