@article{8512774521814a78ac01b6c6d27864ce,
title = "Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor sigma L and roles in virulence and in global regulation of gene expression",
abstract = "In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL-rslA mutant strain was significantly attenuated in a mouse model of infection.",
keywords = "Animals, Base Sequence, Gene Expression Regulation, Bacterial, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred DBA, Molecular Sequence Data, Mycobacterium tuberculosis, Protein Processing, Post-Translational, Sigma Factor, Tuberculosis, Pulmonary, Virulence Factors, Animals, Base Sequence, Gene Expression Regulation, Bacterial, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred DBA, Molecular Sequence Data, Mycobacterium tuberculosis, Protein Processing, Post-Translational, Sigma Factor, Tuberculosis, Pulmonary, Virulence Factors",
author = "Giovanni Delogu and Giovanni Fadda and E Dainese and S Rodrigue and R Provvedi and L Laflamme and R Brzezinski and I Smith and L Gaudreau and G Pal{\`u} and R. Manganelli",
year = "2006",
doi = "10.1128/IAI.74.4.2457-2461.2006",
language = "English",
volume = "74",
pages = "2457--2461",
journal = "Infection and Immunity",
issn = "0019-9567",
publisher = "[Washington, etc.] American Society for Microbiology.",
}