Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor sigma L and roles in virulence and in global regulation of gene expression

Giovanni Delogu, Giovanni Fadda, E Dainese, S Rodrigue, R Provvedi, L Laflamme, R Brzezinski, I Smith, L Gaudreau, G Palù, R. Manganelli

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

49 Citazioni (Scopus)

Abstract

In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL-rslA mutant strain was significantly attenuated in a mouse model of infection.
Lingua originaleEnglish
pagine (da-a)2457-2461
Numero di pagine5
RivistaInfection and Immunity
Volume74
DOI
Stato di pubblicazionePubblicato - 2006

Keywords

  • Animals
  • Base Sequence
  • Gene Expression Regulation, Bacterial
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Molecular Sequence Data
  • Mycobacterium tuberculosis
  • Protein Processing, Post-Translational
  • Sigma Factor
  • Tuberculosis, Pulmonary
  • Virulence Factors

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