Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor sigma L and roles in virulence and in global regulation of gene expression

E Dainese, S Rodrigue, Giovanni Delogu, R Provvedi, L Laflamme, R Brzezinski, Giovanni Fadda, I Smith, L Gaudreau, G Palù, R. Manganelli

Risultato della ricerca: Contributo in rivistaArticolopeer review

50 Citazioni (Scopus)

Abstract

In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL-rslA mutant strain was significantly attenuated in a mouse model of infection.
Lingua originaleInglese
pagine (da-a)2457-2461
Numero di pagine5
RivistaInfection and Immunity
Volume74
Numero di pubblicazione4
DOI
Stato di pubblicazionePubblicato - 2006
Pubblicato esternamente

Keywords

  • Animals
  • Bacterial
  • Base Sequence
  • Gene Expression Regulation
  • Inbred BALB C
  • Inbred C57BL
  • Inbred DBA
  • Mice
  • Molecular Sequence Data
  • Mycobacterium tuberculosis
  • Post-Translational
  • Protein Processing
  • Pulmonary
  • Sigma Factor
  • Tuberculosis
  • Virulence Factors

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