Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor sigma L and roles in virulence and in global regulation of gene expression

E Dainese; S Rodrigue; Giovanni Delogu; R Provvedi; L Laflamme; R Brzezinski; Giovanni Fadda; I Smith; L Gaudreau; G Palù; R. Manganelli

doi:10.1128/IAI.74.4.2457-2461.2006

Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor sigma L and roles in virulence and in global regulation of gene expression

E Dainese, S Rodrigue, Giovanni Delogu, R Provvedi, L Laflamme, R Brzezinski, Giovanni Fadda, I Smith, L Gaudreau, G Palù, R. Manganelli

Risultato della ricerca: Contributo in rivista › Articolo › peer review

50 Citazioni (Scopus)

Abstract

In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL-rslA mutant strain was significantly attenuated in a mouse model of infection.

Lingua originale	Inglese
pagine (da-a)	2457-2461
Numero di pagine	5
Rivista	Infection and Immunity
Volume	74
Numero di pubblicazione	4
DOI	https://doi.org/10.1128/IAI.74.4.2457-2461.2006
Stato di pubblicazione	Pubblicato - 2006
Pubblicato esternamente	Sì

Keywords

Animals
Bacterial
Base Sequence
Gene Expression Regulation
Inbred BALB C
Inbred C57BL
Inbred DBA
Mice
Molecular Sequence Data
Mycobacterium tuberculosis
Post-Translational
Protein Processing
Pulmonary
Sigma Factor
Tuberculosis
Virulence Factors

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10.1128/IAI.74.4.2457-2461.2006

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Dainese, E., Rodrigue, S., Delogu, G., Provvedi, R., Laflamme, L., Brzezinski, R., Fadda, G., Smith, I., Gaudreau, L., Palù, G., & Manganelli, R. (2006). Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor sigma L and roles in virulence and in global regulation of gene expression. Infection and Immunity, 74(4), 2457-2461. https://doi.org/10.1128/IAI.74.4.2457-2461.2006

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title = "Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor sigma L and roles in virulence and in global regulation of gene expression",

abstract = "In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL-rslA mutant strain was significantly attenuated in a mouse model of infection.",

keywords = "Animals, Bacterial, Base Sequence, Gene Expression Regulation, Inbred BALB C, Inbred C57BL, Inbred DBA, Mice, Molecular Sequence Data, Mycobacterium tuberculosis, Post-Translational, Protein Processing, Pulmonary, Sigma Factor, Tuberculosis, Virulence Factors, Animals, Bacterial, Base Sequence, Gene Expression Regulation, Inbred BALB C, Inbred C57BL, Inbred DBA, Mice, Molecular Sequence Data, Mycobacterium tuberculosis, Post-Translational, Protein Processing, Pulmonary, Sigma Factor, Tuberculosis, Virulence Factors",

author = "E Dainese and S Rodrigue and Giovanni Delogu and R Provvedi and L Laflamme and R Brzezinski and Giovanni Fadda and I Smith and L Gaudreau and G Pal{\`u} and R. Manganelli",

year = "2006",

doi = "10.1128/IAI.74.4.2457-2461.2006",

language = "English",

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pages = "2457--2461",

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Dainese, E, Rodrigue, S, Delogu, G, Provvedi, R, Laflamme, L, Brzezinski, R, Fadda, G, Smith, I, Gaudreau, L, Palù, G & Manganelli, R 2006, 'Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor sigma L and roles in virulence and in global regulation of gene expression', Infection and Immunity, vol. 74, n. 4, pagg. 2457-2461. https://doi.org/10.1128/IAI.74.4.2457-2461.2006

TY - JOUR

T1 - Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor sigma L and roles in virulence and in global regulation of gene expression

AU - Dainese, E

AU - Rodrigue, S

AU - Delogu, Giovanni

AU - Provvedi, R

AU - Laflamme, L

AU - Brzezinski, R

AU - Fadda, Giovanni

AU - Smith, I

AU - Gaudreau, L

AU - Palù, G

AU - Manganelli, R.

PY - 2006

Y1 - 2006

N2 - In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL-rslA mutant strain was significantly attenuated in a mouse model of infection.

AB - In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL-rslA mutant strain was significantly attenuated in a mouse model of infection.

KW - Animals

KW - Bacterial

KW - Base Sequence

KW - Gene Expression Regulation

KW - Inbred BALB C

KW - Inbred C57BL

KW - Inbred DBA

KW - Mice

KW - Molecular Sequence Data

KW - Mycobacterium tuberculosis

KW - Post-Translational

KW - Protein Processing

KW - Pulmonary

KW - Sigma Factor

KW - Tuberculosis

KW - Virulence Factors

KW - Animals

KW - Bacterial

KW - Base Sequence

KW - Gene Expression Regulation

KW - Inbred BALB C

KW - Inbred C57BL

KW - Inbred DBA

KW - Mice

KW - Molecular Sequence Data

KW - Mycobacterium tuberculosis

KW - Post-Translational

KW - Protein Processing

KW - Pulmonary

KW - Sigma Factor

KW - Tuberculosis

KW - Virulence Factors

UR - https://publicatt.unicatt.it/handle/10807/6594

U2 - 10.1128/IAI.74.4.2457-2461.2006

DO - 10.1128/IAI.74.4.2457-2461.2006

M3 - Article

SN - 0019-9567

VL - 74

SP - 2457

EP - 2461

JO - Infection and Immunity

JF - Infection and Immunity

IS - 4

ER -

Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor sigma L and roles in virulence and in global regulation of gene expression

Abstract

Keywords

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