Postoperative intensity modulated radiation therapy in high risk prostate cancer: a dosimetric comparison

Francesco Deodato, Gian Carlo Mattiucci, Vincenzo Valentini, Savino Cilla, Anna Maria De Gaetano, Mariangela Massaccesi, Gabriella Macchia, Edy Ippolito, Simona Panunzi, Elisa D'Angelo, Numa Cellini, Angelo Piermattei, Alessio Giuseppe Morganti, Cinzia Digesú, C Iapalucci, Gda Padula

Risultato della ricerca: Contributo in rivistaArticolo in rivista

9 Citazioni (Scopus)

Abstract

The aim of this study was to compare intensity-modulated radiation therapy (IMRT) with 3D conformal technique (3D-CRT), with respect to target coverage and irradiation of organs at risk for high dose postoperative radiotherapy (PORT) of the prostate fossa. 3D-CRT and IMRT treatment plans were compared with respect to dose to the rectum and bladder. The dosimetric comparison was carried out in 15 patients considering 2 different scenarios: (1) exclusive prostate fossa irradiation, and (2) pelvic node irradiation followed by a boost on the prostate fossa. In scenario (1), a 3D-CRT plan (box technique) and an IMRT plan were calculated and compared for each patient. In scenario (2), 3 treatment plans were calculated and compared for each patient: (a) 3D-CRT box technique for both pelvic (prophylactic nodal irradiation) and prostate fossa irradiation (3D-CRT only); (b) 3D-CRT box technique for pelvic irradiation followed by an IMRT boost to the prostatic fossa (hybrid 3D-CRT and IMRT); and (c) IMRT for both pelvic and prostate fossa irradiation (IMRT only). For exclusive prostate fossa irradiation, IMRT significantly reduced the dose to the rectum (lower Dmean, V50%, V75%, V90%, V100%, EUD, and NTCP) and the bladder (lower Dmean, V50%, V90%, EUD and NTCP). When prophylactic irradiation of the pelvis was also considered, plan C (IMRT only) performed better than plan B (hybrid 3D-CRT and IMRT) as respect to both rectum and bladder irradiation (reduction of Dmean, V50%, V75%, V90%, equivalent uniform dose [EUD], and normal tissue complication probability [NTCP]). Plan (b) (hybrid 3D-CRT and IMRT) performed better than plan (a) (3D-CRT only) with respect to dose to the rectum (lower Dmean, V75%, V90%, V100%, EUD, and NTCP) and the bladder (Dmean, EUD, and NTCP). Postoperative IMRT in prostate cancer significantly reduces rectum and bladder irradiation compared with 3D-CRT.
Lingua originaleEnglish
pagine (da-a)231-239
Numero di pagine9
RivistaMedical Dosimetry
Volume36
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Aged
  • Combined Modality Therapy
  • Humans
  • Male
  • Middle Aged
  • Prostatic Neoplasms
  • Radiometry
  • Radiotherapy Dosage
  • Radiotherapy, Intensity-Modulated

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