Possible contribution of IMRT in postoperative radiochemotherapy for rectal cancer: Analysis on 1798 patients by prediction model

Maria Antonietta Gambacorta, Vincenzo Valentini, Nicola Dinapoli, Elisa Meldolesi, Giuditta Chiloiro, Wen-Yang Liu, Xin Wang, Hua Ren, Hui Fang, Ning-Ning Lu, Yu Tang, Lei Deng, Jian-Yang Wang, Hao Jing, Qin Xiao, Yan-Ru Feng, Ye-Xiong Li, Shu-Lian Wang, Yong-Wen Song, Yue-Ping LiuWei-Hu Wang, Jing Jin

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

The evidence for adjuvant therapy in locally advanced rectal cancer after TME surgery is sparse. The aim of this study was to identify predicting factors of overall survival (OS) in these patients and combine them into a nomogram for individualized treatment. 1798 patients with pathologically staged II/III rectal adenocarcinoma treated by radical TME surgery from a single center's database were reviewed. The nomogram was derived by Cox proportional hazards regression. Its performance was assessed by concordance index and calibration curve in internal validation with bootstrapping. Pooled Cox model analysis identified age, sex, grade of histology, pathological T and N stage, residual tumor, concurrent radiochemotherapy (RTCT), adjuvant chemotherapy cycles (CT), radiotherapy (RT) unexpected interruption days and intensity-modulated radiation therapy (IMRT) as significant covariates for 5-year OS (P < 0.05). Postoperative RTCT, CT and IMRT all improved OS. The proposed model can predict 5-year OS with a C-index of 0.7105. IMRT significantly benefited OS in multivariate analysis (p=0.0441). In conclusion, our nomogram can predict 5-year OS after TME surgery for locally advanced rectal cancer with simple and effective advantage. This model may provide not only baseline OS estimate but also a tool for candidates selecting of adjuvant treatment in prospective studies.
Lingua originaleEnglish
pagine (da-a)46536-46544
Numero di pagine9
RivistaOncotarget
Volume7
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • Intensity-modulated radiation therapy
  • Nomogram
  • Oncology
  • Postoperative radiochemotherapy
  • Rectal cancer
  • Survival

Fingerprint

Entra nei temi di ricerca di 'Possible contribution of IMRT in postoperative radiochemotherapy for rectal cancer: Analysis on 1798 patients by prediction model'. Insieme formano una fingerprint unica.

Cita questo